Results 101 to 110 of about 12,171,189 (307)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Extreme event attribution using km-scale simulations reveals the pronounced role of climate change in the Durban floods

Communications Earth & Environment
The Durban floods of 11–12 April 2022 is the worst flood disaster in South Africa’s history and raised questions about the role of climate change in the event. Meso-scale dynamics, involving processes that cannot be resolved at the spatial resolutions of
Francois A. Engelbrecht, Jessica Steinkopf, Nicolette Chang, Sophie Biskop, Johan Malherbe, Christien J. Engelbrecht, Stefan Grab, Alize le Roux, Coleen Vogel, Jonathan Padavatan, Marcus Thatcher, John L. McGregor   +11 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Gaming the unknown: learning to differentiate and respond to uncertainty through a serious game

npj Climate Action
Effective climate adaptation planning requires understanding various sources and types of uncertainty. We investigated how a serious game can improve participants’ understanding of uncertainty in adaptation decision-making.
Wout Jan-Willem Sommerauer, Bregje van der Bolt, Saskia Werners, Wouter Julius Smolenaars, Marlies van Ree, Fulco Ludwig   +5 more
doaj   +1 more source

State Adaptation Plans [PDF]

, 2010
This map shows states with plans for adapting to global climate ...
Pew Center on Global Climate Change
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Issues : global change - climate change and variability / risk - vulnerability / research - capacity building - governance / science - communication - decision processes

, 2007
PowerPoint presentationThe presentation covers precipitation patterns and climate anomalies in Brazil. It then reviews partnerships with climate change research groups in North and South America.
Inter-American Institute for Global Change Research (IAI)
core   +1 more source

Global Climate Change Impacts in the United States [Brochure]

, 2009
The report highlighted in this brochure summarizes the science of climate change and the impacts of climate change on the United State, now and in the ...
U.S. Global Change Research Program
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Traceable and Scalable Food Balance Sheets from Agricultural Commodity Supply and Utilization Accounts (2010–2022)

Scientific Data
The Food Balance Sheets (FBS), compiled by the Food and Agriculture Organization (FAO), serve as a cornerstone dataset for studies on agricultural development, food security, and dietary health, providing a broad overview of global and regional food ...
Xin Zhao, Maksym Chepeliev, Neus Escobar, Matthew T. Binsted, Pralit Patel, Page Kyle, Marshall A. Wise   +6 more
doaj   +1 more source