Results 171 to 180 of about 6,711,226 (342)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

MOESM7 of Global changes in the proteome of Cupriavidus necator H16 during poly-(3-hydroxybutyrate) synthesis from various biodiesel by-product substrates

, 2016
Parveen Sharma, Jilagamazhi Fu, Victor Spicer, Oleg V. Krokhin, Nazim Çiçek, Richard Sparling, David B. Levin   +6 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Global Climate Change and the Funding of Adaptation [PDF]

Mitigation and adaptation are the most important strategies in combating global climate change. It is expected that in a post Kyoto world industrialized countries have to engage in greenhouse gas abatement, and to support developing countries in adapting
Gunter Stephan, Seraina Buob
core  

Integrating HIV services in an era of global change. [PDF]

J Int AIDS Soc
Ratevosian J, Bekker LG, Eakle R, Baral S, Cepeda J, Dugas L, Dybul M, Alleyne G, Eholie SP, Esom K, Grimsrud A, Havlir D, Kamarulzaman A, Kasaie P, Kazatchkine M, Kilonzo N, Klag M, Klein M, Lewin S, Luo C, Makofane K, Martin N, Mayer K, Millett G, Ntusi N, Pace L, Piot P, Poniatowski B, Daskalakis D, Pozniak A, Quinn T, Reynolds C, Rockstroh J, Sippel S, Spire B, Starrs A, Strathdee S, Schechter M, Thomson N, Vickerman P, Weir B, Beyrer C.   +41 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

China's Trade‐Off Between Economic Benefits and Sulfur Dioxide Emissions in Changing Global Trade [PDF]

, 2020
Feng Wang, Yongyuan Li, Wei Zhang, Pan He, Ling Jiang, Beiming Cai, Jing Zhang, Pengyan Zhang, Haoran Pan, Hongqiang Jiang   +9 more
openalex   +1 more source

Observing Global Change in the Tropics [PDF]

, 2008
Wallace, Douglas W.R.
core  

Congo Basin Carbon Cycle Responses to Global Change. [PDF]

Glob Chang Biol
Worden S, Fu R, Bloom AA, Bauters M, Verbeeck H, Fatoyinbo T, Hubau W, Koutika LS, Kengdo SK, Maes SL, Medjibe V, Russo NJ, Saatchi S, Sagang LB, Smith TB, Sonwa DJ, Boeckx P, Ordway EM.   +17 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source