Results 111 to 120 of about 15,173 (297)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

La formación profesional continua y los agentes de formación: un grupo ocupacional hacia la profesionalización [PDF]

, 1996
[spa] La tesis aborda el tema de la formación permanente de adultos en el mundo laboral (formación profesional continua). Ofrece una visión global de lo que es hoy en dia esta formación en las sociedades avanzadas, caracterizadas por los cambios ...
Rubio Hurtado, María José
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

PERCEPCIÓN DE LA CULTURA DE LA SEGURIDAD DE LOS PACIENTES POR PERSONAL DE ENFERMERÍA

Ciencia y Enfermería
Objetivo: Identificar las áreas de fortaleza y oportunidad de mejora continua, percibidas por el personal de enfermería en relación a la cultura de seguridad en la atención de los pacientes en un Hospital General del Sistema de Salud, en Tampico ...
Hortensia Castañeda-Hidalgo, Rosalinda Garza Hernández, Juana Fernanda González Salinas, Mercedes Pineda Zúñiga, Gloria Acevedo Porras, Angélica Aguilera Pérez   +5 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Optimización global de funciones continuas

, 2011
versión ...
openaire   +1 more source

Estudio, modelado, simulación y optimización de los convertidores continua-continua de estructura resonante con carga en paralelo

, 1989
En el presente trabajo se aborda el estudio de los convertidores continua-continua de estructura resonante con carga en paralelo. Su objetivo es el desarrollo de una metodología de análisis que permita el modelado de estos convertidores, tanto en régimen
Rico Secades, Manuel
core  

Malm, Andreas. A destruição da Palestina é a destruição do Planeta. Tradução de Natalia Engler. 1. ed. São Paulo: Editora Elefante, 2024. ISBN 978-65-88465-57-5 | Malm, Andreas. The Destruction of Palestine is the Destruction of the Planet. Translated by Natalia Engler. 1st ed. São Paulo: Editora Elefante, 2024. ISBN 978-65-88465-57-5

Mural Internacional
O ensaio de Andreas Malm propõe uma interpretação radical e histórica da conexão entre o imperialismo fóssil e a destruição sistemática da Palestina. A partir do bombardeio britânico à cidade de Akka em 1840, o autor constrói uma linha contínua entre o ...
Luis Otávio Vilela da Cruz
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source