Results 91 to 100 of about 15,173 (297)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

In memoriam: La plataforma massmediática como dispositivo de emancipación

open access: yesCampos en Ciencias Sociales, 2013
El texto recorre la postura que han tenido varios autores, quienes, a pesar de las diferencias, han encontrado en las tecnologías de la comunicación un elemento que determina el fenómeno de la globalización. Continúa la reflexión para establecer cómo la
Liliana Rocío Torres López
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

La amenaza intratable: El terrorismo y el nuevo orden estratégico global

open access: yesDesafíos, 2017
El autor establece un marco conceptual para el tratamiento del problema del terrorismo internacional en el mundo contemporáneo. Comienza con consideraciones sobre la "crisis  permanente" como característica del  sistema global, y sobre la capacidad de ...
Vicente Torrijos
doaj  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Biological tissue mechanics with fibres modelled as one dimensional Cosserat continua: applications to cardiac tissue in healthy and diseased states

open access: yes, 2014
Includes bibliographical references.Classically, the elastic behaviour of cardiac tissue mechanics is modelled using anisotropic strain energy functions capturing the averaged behaviour of its fibrous microstructure.
Kevin Sack, Sack, Kevin
core  

Marketing global: conceito ou mito?

open access: yesRAE: Revista de Administração de Empresas, 1993
O conceito de Marketing Global, desenvolvido por Theodore Levitt, e considerado como um dos mais polêmicos dentro da literatura de Marketing. Este ano, o conceito completa dez anos e continua a gerar polêmica entre os estudiosos e praticantes do ...
Carlos Alcides Salles
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Mechanics of granular materials: The discrete and the continuum descriptions juxtaposed

open access: yes, 2006
In recent years a discussion could be followed where the pros and cons of the applicability of the Cosserat continuum model to granular materials were debated [Bardet, J.P., Vardoulakis, I., 2001. The asymmetry of stress in granular media. Int. J. Solids
Froiio, F   +6 more
core   +1 more source

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