Results 81 to 90 of about 5,786 (253)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tratamiento Quirúrgico del Cáncer del Pulmón
Revista Colombiana de Cirugía, 1989 Se revisan los principales aspectos relacionados con el diagnóstico, clasificación y tratamiento del f...áncer del pulmón. Infortunadamente, a pesar de los grandes avances obtenidos.
Juan Camilo Ramírez +2 more
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Arte, Diseño e Ingeniería, 2015 ResumenLa comunidad universitaria no podía ser ajena a las actividades de cooperación,cuyo principal objetivo es la transformación de la sociedad en busca de loseternos ideales de lograr una sociedad más justa, más libre, a través del desarrollo global ...
José Antonio Mancebo Piqueras +3 more
doaj
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Hacia una historia global descolonizada: una perspectiva latinoamericana
EsboçosLa historia global está en auge desde hace más de dos décadas. Sin embargo, a diferencia de Europa, Estados Unidos y Asia, donde se puede observar un verdadero “boom” de esta perspectiva, en Latinoamérica no ha tenido tanto impacto hasta ahora; incluso ...
Gabriela de Lima Grecco, Sven Schuster
doaj +1 more source
, 2023 Esta breve comunicación intenta hacer reflexionar sobre el desarrollo a todos los niveles que se puedan evaluar en el bienestar humano desde un desarrollo local, hacia una escala global o planetaria. Y en este sentido los principales ejes en los cuales se basa son sobre la importancia en la vinculación de los individuos en sus cercanías al igual que a ...
Bracamonte Gontero, Lucia V. +1 more
openaire +1 more source