Results 41 to 50 of about 191,229 (265)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Study on Steady State Power Model of Concentrated Solar Power With Heat Storage System

发电技术, 2022
Concentrated solar power (CSP) with heat storage system, as a clean power, owns the capability of generating power continuously and stably, peak shaving and providing system inertia, which is one of the technologies to effectively solve the volatility of
ZHANG Zedong, WANG Wei, YE Jilei, SHEN Hong   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Public views of health insurance in Japan during the era of attaining universal health coverage: a secondary analysis of an opinion poll on health insurance in 1967

Journal of Public Health Research, 2017
While Japan’s success in achieving universal health insurance over a short period with controlled healthcare costs has been studied from various perspectives, that of beneficiaries have been overlooked.
Ikuma Nozaki, Koji Wada, Osamu Utsunomiya   +2 more
doaj   +1 more source

Japan’s development cooperation for health in Vietnam: a first holistic assessment on Japan’s ODA and non-ODA public resources cooperation

BMC Public Health, 2021
Background Japan strives to strengthen its development cooperation by mobilizing various resources to assist partner countries advance on Universal Health Coverage by 2030.
Sangnim Lee, Aya Ishizuka, Hisateru Tachimori, Manami Uechi, Hidechika Akashi, Eiji Hinoshita, Hiroaki Miyata, Kenji Shibuya   +7 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Challenges and opportunities for eliminating tuberculosis – leveraging political momentum of the UN high-level meeting on tuberculosis

BMC Public Health, 2019
Background As demonstrated by the United Nations High-Level Meeting on tuberculosis (TB) held in September 2018, the political momentum for TB has been increasing.
Haruka Sakamoto, Sangnim Lee, Aya Ishizuka, Eiji Hinoshita, Hiroyuki Hori, Nanao Ishibashi, Kenichi Komada, Masataro Norizuki, Yasushi Katsuma, Hidechika Akashi, Kenji Shibuya   +10 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

WID, GAD or Somewhere Else? A critical analysis of gender in Korea's international education and development

Journal of Contemporary Eastern Asia, 2019
Over the past few decades, gender equality has been considered one of the fundamental principles and a significant crosscutting issue in international development.
Lee, Ji Min, Yoo, Sung-Sang, Hong, Moon Suk   +2 more
doaj   +1 more source

From cooperation to globalization [PDF]

Annals of Spiru Haret University Economic Series, 2010
Globalization is seen as a consequence of cross-border business. This complex and irreversible process can be seen as an extension of capitalist relations of production or increased interdependence in the economic system. Globalization has given rise to more and more fields of activity worldwide.
openaire   +2 more sources