Results 51 to 60 of about 191,229 (265)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Infection control teams for reducing healthcare-associated infections in hospitals and other healthcare settings: a protocol for systematic review

BMJ Open, 2021
Introduction Healthcare-associated infections (HCAIs) are a worldwide problem. Infection control in hospitals is usually implemented by an infection control team (ICT).
Erika Ota, Moe Moe Thandar, Sadatoshi Matsuoka, Obaidur Rahman, Toshiaki Baba   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Culture, 'Relationality‘, and Global Cooperation

, 2014
What is the relationship between cultural difference and global cooperation, and what challenges and opportunities does this relationship pose for cooperation research? This paper examines how culture is a potential resource for global cooperation while grappling with its enigmas and ambiguities.
openaire   +7 more sources

On Cooperative Coevolution and Global Crossover

IEEE Transactions on Evolutionary Computation
Cooperative coevolutionary algorithms (CCEAs) divide a given problem in to a number of subproblems and use an evolutionary algorithm to solve each subproblem. This short paper is concerned with the scenario under which only a single, global fitness measure exists. By removing the typically used subproblem partnering mechanism, it is suggested that such
Larry Bull, Haixia Liu 0001
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Influence of customer satisfaction and perceived water service quality on urban water supply management: A systematic review

Cleaner and Responsible Consumption
Previous studies have found relationships among customer satisfaction, the management of water utilities, and users' willingness to pay (WTP) for improved water service quality. However, these studies have captured only part of the water supply situation
Ryuji Ogata, Shigeyuki Matsumoto, Takahiro Otsuka, Yoko Hattori, Hidetoshi Kitawaki   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Risk-return analysis of clean energy grid project investment based on integrated ISM and Monte Carlo model

EAI Endorsed Transactions on Energy Web
To solve the problem of complex and difficult to quantify factors affecting investment returns and risks in clean energy power grids, this study comprehensively applies the interpretive structural model and Monte Carlo model to the analysis of ...
Shu Li, Junyong Xiang, Rong Li, Duo Wang
doaj   +1 more source

Mechanism of CO2 Emission Reduction by Global Energy Interconnection

Global Energy Interconnection, 2018
The challenge of global warming has become a driving force for a global energy transition. The Global Energy Interconnection (GEI) is a modern energy system aimed at meeting the global power demand in a clean and green manner.
Yuanbing Zhou, Xing Chen, Xin Tan, Changyi Liu, Shining Zhang, Fang Yang, Wenji Zhou, Han Huang   +7 more
doaj   +1 more source