Global Existence and Decay Rate of Smooth Solutions for Full System of Partial Differential Equations for Three-Dimensional Compressible Magnetohydrodynamic Flows [PDF]
, 2023 M. Abdallah, Zhong Tan
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Global existence and asymptotic stability of smooth solutions to a fluid dynamics model of biofilms in one space dimension [PDF]
, 2015 Roberta Bianchini, Roberto Natalini
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Global existence and Asymptotic behavior for a system of wave equation in presence of distributed delay term [PDF]
, 2018 Akram Ben Aissa +2 more
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Existence of large-data global weak solutions to a model of a strain-limiting viscoelastic body [PDF]
, 2020 Miroslav Bulíček +3 more
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Energy decay for wave equations of phi-Laplacian type with weakly nonlinear dissipation
Electronic Journal of Differential Equations, 2008 In this paper, first we prove the existence of global solutions in Sobolev spaces for the initial boundary value problem of the wave equation of $phi$-Laplacian with a general dissipation of the form $$ (|u'|^{l-2}u')'-Delta_{phi}u+sigma(t) g(u')=0 ...
Aissa Guesmia, Abbes Benaissa
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