Results 101 to 110 of about 5,131,625 (338)

Plastic pollution challenges in marine and coastal environments: from local to global governance

open access: yes, 2017
Plastic pollution in the marine and coastal environment is a challenging restoration and governance issue. Similar to many environmental problems, marine plastic pollution is transboundary and therefore the governance solutions are complex.
J. Vince, B. D. Hardesty
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Doing (and undoing) privilege: evaluating how public policy drives health inequities

open access: yesCritical Public Health
In an era marked by persistent health inequities, this commentary moves beyond the conventional focus on disadvantage and individual-level interventions to present novel conceptual and analytical thinking that illuminates the role of structurally ...
Ashley Schram   +10 more
doaj   +1 more source

Utilization of healthcare services among Chinese migrants in Kenya: a qualitative study

open access: yesBMC Health Services Research, 2019
Background The number of Chinese migrants in Sub-Saharan Africa (SSA) is increasing, which is part of the south-south migration. The healthcare seeking challenges for Chinese migrants in Africa are different from local people and other global migrants ...
Jialing Qiu   +8 more
doaj   +1 more source

The Country Connector on Private Sector in Health: a global governance platform. [PDF]

open access: yesBMJ Glob Health, 2023
Clarke D   +6 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

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