Results 111 to 120 of about 1,195,865 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Right to science principles should guide global governance on health. [PDF]

Front Sociol, 2023
Dang G, Frick M.
europepmc   +1 more source

Synthesis report: Third International Conference on Corporate Governance in Emerging Market [PDF]

, 2011
The Third International Conference on Corporate Governance in Emerging Markets is one in a series of academic events organized by the Emerging Markets Corporate Governance Network (EMCGN).
Ararat, Melsa, Claessens, Stijn, Yurtoglu, Burcin B., Yurtoğlu, Burçin B.   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Doing (and undoing) privilege: evaluating how public policy drives health inequities

Critical Public Health
In an era marked by persistent health inequities, this commentary moves beyond the conventional focus on disadvantage and individual-level interventions to present novel conceptual and analytical thinking that illuminates the role of structurally ...
Ashley Schram, Amy Carrad, Belinda Townsend, Patrick Harris, Fran Baum, Lucie Rychetnik, Steven Allender, Melanie Pescud, Nicholas Frank, Megan Arthur, Sharon Friel   +10 more
doaj   +1 more source

Global governance for pandemic prevention and the wildlife trade. [PDF]

Lancet Planet Health, 2023
Gallo-Cajiao E, Lieberman S, Dolšak N, Prakash A, Labonté R, Biggs D, Franklin C, Morrison TH, Viens AM, Fuller RA, Aguiar R, Fidelman P, Watson JEM, Aenishaenslin C, Wiktorowicz M.   +14 more
europepmc   +1 more source

THE SEMANTICS OF GOVERNANCE. (The common thread running through corporate, public, and global governance.) [PDF]

This paper argues that the semantics of governance illustrates connections and provides a unifying view from which to understand much better its natural branches: corporate, public and global governance.
Rodolfo Apreda
core  

Renewal through Participation in Global Food Security Governance: Implementing the International Food Security and Nutrition Civil Society Mechanism to the Committee on World Food Security [PDF]

, 2012
The food commodity price rises from 2006 to 2008 engendered a period of political renewal and reform in the governance of global food security. The Committee on World Food Security (CFS) was designated as the main international forum dealing with food ...
Barling, D., Duncan, J.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source