Results 131 to 140 of about 196,888 (267)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Actors and Agency in Global Social Governance

, 2015
The introduction paves the way for an actor-centred approach to global social governance. The chapter highlights the necessity to think beyond existing conceptualizations and approaches, by combining different analytical tools from social policy ...
Kaasch, Alexandra, Martens, Kerstin
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Capitalising (on) industrial epidemics: examining the influence of the ‘Big Three’ asset managers on corporate governance in key health-harming commodity industries

Globalization and Health
Background In recent decades, the Big Three asset managers (BlackRock, Vanguard, State Street) have emerged to be among the top shareholders in thousands of listed companies worldwide.
Benjamin Wood, Scott Slater, Sharon Friel, Ashley Schram, Nicholas Frank, Gary Sacks   +5 more
doaj   +1 more source

Hybrid institutional complexes in global governance. [PDF]

Rev Int Organ, 2022
Abbott KW, Faude B.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

China's Complex Leadership in G20 and Global Governance: From Hangzhou 2016 to Kunming 2021. [PDF]

Chin Polit Sci Rev, 2022
Kirton J, Wang AX.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Opinion: Toward inclusive global governance of human genome editing. [PDF]

Proc Natl Acad Sci U S A, 2021
Yu H, Xue L, Barrangou R, Chen S, Huang Y.   +4 more
europepmc   +1 more source

The Financial Crisis - Global Governance Failure? [PDF]

The asymmetries created by the non-conventional threats tend to lean the international security toward its human approach. Nevertheless, we now have to deal with the need for international cooperation and with finding complex solution to complex global ...
Laura AFRÃSINE
core