Results 131 to 140 of about 5,856,508 (299)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
China's LNG import risk assessment based on the perspective of global governance. [PDF]
Sci Rep, 2022 Zeng W, Zhang X, Li N, Wang X, Wang X.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Global Governance and Domestic Politics: Fragmented Visions
, 2005 Global governance is mostly studied as a top-down project. The meaning of the concept is analyzed and investigated from the perspective of a designated concept of the “global.” Such investigations focus rightfully on questions such as “How is the global ...
Ergun Özbolat, Ayça
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Hybrid institutional complexes in global governance. [PDF]
Rev Int Organ, 2022 Abbott KW, Faude B.
europepmc +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Journal of Infection in Developing CountriesIntroduction: Antimicrobials are vital for human and animal health; however, their improper use leads to antimicrobial resistance. Shared living spaces and close bonds between humans and pets raise concerns about transferring resistant pathogens from ...
Sneha Elsa Sam, Rinila Das, Navya Vyas
doaj +1 more source
China's Complex Leadership in G20 and Global Governance: From Hangzhou 2016 to Kunming 2021. [PDF]
Chin Polit Sci Rev, 2022 Kirton J, Wang AX.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source