Results 61 to 70 of about 5,355,108 (382)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
The disease of corruption: views on how to fight corruption to advance 21st century global health goals [PDF]
, 2016 Corruption has been described as a disease. When corruption infiltrates global health, it can be particularly devastating, threatening hard gained improvements in human and economic development, international security, and population health.
Clare, Jillian +6 more
core +1 more source
PLOS Global Public Health, 2023 [This corrects the article DOI: 10.1371/journal.pgph.0002129.].
PLOS Global Public Health Staff
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Global Health in Lights: Hollywood's Master Storytellers & Stars Highlight Global Health in Entertainment [PDF]
, 2011 Sandra de Castro Buffington, director of the Norman Lear Center's Hollywood, Health & Society program, moderated this discussion which brought top TV producers, writers and performers together with key Washington policymakers to focus on how global ...
core
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
FEBS Letters, EarlyView.Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston +7 more
wiley +1 more source
Developing Successful Global Health Alliances [PDF]
, 2002 Examines the circumstances that call for alliance formation to reduce the burdens of AIDS, tuberculosis, malaria, polio, river blindness, and many other diseases; the utility of various alliance models; and the characteristics of successful ...
core
Re-DPoctor: Real-time health data releasing with w-day differential privacy [PDF]
arXiv, 2017 Wearable devices enable users to collect health data and share them with healthcare providers for improved health service. Since health data contain privacy-sensitive information, unprotected data release system may result in privacy leakage problem. Most of the existing work use differential privacy for private data release.
arxiv