Results 61 to 70 of about 6,577,395 (253)

John North Collection [PDF]

open access: yes, 1944
Letter from John North to his family about his time in boot camp in the United States Navy. This letter talks about being on guard duty and how he is guarding the laundry room.
North, John
core   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

U.S. Global Change Research Program Program Overview: USGCRP At A Glance [PDF]

open access: yes
This fact sheet presents an overview of the U.S.
U.S. Global Change Research Program
core  

Climate change movements in the Global North

open access: yes, 2021
The climate change movement in the Global North developed after years of scientific evidence accumulated on the topic. Even in those early years, however, it was members of environmental non-governmental organizations (ENGOs) who ensured that policymakers would begin to act.
openaire   +3 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Framing and Contesting the Dominant Global Imaginary of North-South Relations: Identifying and Challenging Socio-Cultural Hierarchies [PDF]

open access: yes, 2015
In this article, we draw selectively on postcolonial theory to identify problematic patterns of knowledge production and engagement that have historically conditioned a dominant global imaginary grounded on a single story of development and on ...
Hanna Alasuutari, Vanessa Andreotti
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

Global Studies Faculty Seminar: September 2013 Meeting [audio] [PDF]

open access: yes, 2013
This audio recording is of the University of North Texas Global Studies Faculty Seminar September 2013 ...

core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

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