Results 81 to 90 of about 2,964,939 (305)

From global north to south: governing contaminants of emerging concern in water systems

open access: yesEnvironmental Research Letters
Contaminants of emerging concern (CECs), notably per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, and microplastics (MPs), are increasingly detected in water systems, posing growing risks to ecosystems, human health, and socio-economic ...
Nhlanhla Hlongwa   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Exploring collaboration patterns among global software development teams. [PDF]

open access: yes, 2009
This study examines communication behaviors in global software student teams. The authors of the paper characterize the types of communication behaviors that occur when student teams are engaged in a software development project. The authors present
Alpaslan, Ferda Nur   +6 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Debt and development [PDF]

open access: yes, 2012
Sets out the roots of the debt crises of the 1980s and 2000s, and shows the similarities between the most recent financial crisis in the North and earlier debt crises in the Global South.
Hanlon, Joseph
core  

Changes in global ocean bottom properties and volume transports in CMIP5 models under climate change scenarios [PDF]

open access: yes, 2014
Changes in bottom temperature, salinity and density in the global ocean by 2100 for CMIP5 climate models are investigated for the climate change scenarios RCP4.5 and RCP8.5.
Arora   +68 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Genesis, Pathways, and Terminations of Intense Global Water Vapor Transport in Association with Large-Scale Climate Patterns [PDF]

open access: yes, 2017
The CONNected objECT (CONNECT) algorithm is applied to global Integrated Water Vapor Transport data from the NASA's Modern-Era Retrospective Analysis for Research and Applications – Version 2 reanalysis product for the period of 1980 to 2016.
Kawzenuk, B   +4 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Organic farming and fair trade in developing country as a new agribusiness paradigm: Evidence from Mali [PDF]

open access: yes
Organic farming and fair trade certified chains have emerged in West-Africa since the 1990s in answer to new alternative markets in developed countries.
Bastiaensen, Johan   +4 more
core   +1 more source

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