Results 101 to 110 of about 7,124,818 (299)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Global Models and North-South Relations [PDF]
International Political Science Review, 1990 Global modeling has evolved remarkably in the last two decades. Such evolution led it to perform today's role as an experimental laboratory for the social sciences, and particularly for applications to policy planning. Two of the most interesting applications to policy are to resource economics and to economic models of North-South relations, i.e., the
openaire +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
W49A North: Global or Local or No Collapse?
The Astrophysical Journal Supplement Series, 2004 42 pages, 27 figures, accepted for publication in the ApJS August 2004, v153 ...
Williams, John A. +2 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The problem of ‘trickle-down science’ from the Global North to the Global South
BMJ Global Health, 2019 ### Summary box Trickle-down economics holds that the way to lift the poor out of poverty is to support wealth creation in those who are already rich.1 The underlying assumption is that as the wealth of the rich grows, they will purchase more goods and ...
D. Reidpath, P. Allotey
semanticscholar +1 more source
Adopting a Universal Mandate on Platform Work: Balancing Contrasting Realities
Tilburg Law ReviewThe challenges that present-day globalization poses in setting international labour standards are not uncharted. The conflict between the role of global considerations, on the one hand, and national and local dimensions, on the other, is one well-known ...
Juliana Londoño Polo
doaj +1 more source
Epigenetics, 2019 The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that in utero and early life conditions can disrupt normal fetal development and program susceptibility to later-life disease.
Jeliyah Clark +6 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source