Results 131 to 140 of about 5,020,641 (311)
Constrained Global Optimization by Smoothing
This paper proposes a novel technique called "successive stochastic smoothing" that optimizes nonsmooth and discontinuous functions while considering various constraints. Our methodology enables local and global optimization, making it a powerful tool for many applications.
Vladimir I. Norkin +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Optimality Theory and Minimalism: A Possible Convergence?
, 2006 This issue of Linguistics in Potsdam contains a number of papers that grew out of the workshop Descriptive and Empirical Adequacy in Linguistics held in Berlin on December 17-19 December, 2005.
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Derivational Phonology and Optimality Phonology: Formal Comparison and Synthesis
, 2003 This thesis conducts a formal comparison of Optimality Theoretic phonology with its predecessor, Rule-based Derivational phonology. This is done in three studies comparing (i) rule operations and Faithfulness constraint violations, (ii) serial rule ...
Norton, Russell James
core +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Optimality Theory and the Minimalist Program
, 2006 In this paper I argue that an OT-approach to grammar is actually essential to minimalist investigations, because it dramatically widens the set of linguistic properties potentially reducible to interface conditions while at the same time dispensing with ...
core
A new analytical envelope for multivariate global optimization
Journal of Numerical Analysis and Approximation TheoryWe propose a new global optimization method that combines an α–dense univariate reduction with explicitly constructed analytical envelopes: a piecewise concave underestimator (PCU) and a piecewise convex overestimator (PCO).
Djamel Aaid
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source