Results 111 to 120 of about 6,868 (254)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Global optimality conditions for quadratic 0-1 optimization problems
Global optimization, Quadratic programming, Global optimality condition, Quadratic 0-1 programming, Half-products,
Liansheng Zhang, Wei Chen
core +1 more source
Global Optimality Bounds for ICA Algorithms [PDF]
, 2016 peer reviewedIndependent Component Analysis is a popular statistical method for separating a multivariate signal into additive components. It has been shown that the signal separation problem can be reduced to the joint diagonalization of the matrix ...
COLOMBO, Nicolo +2 more
core
, 2021 The segmental phonology of English comprises of vowels and consonants, which are critical in the process of second language learnability. The Sibilants of RP English are /s, z, ʃ,ʒ, ʤ,ʧ/ which consists of fricatives and affricates.
Ayieko, Gerry
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Optimization of mechanical structures using interval analysis
Computer Assisted Methods in Engineering and Science, 2023 The problem of optimal design consists in finding the optimum parameters according to a specified optimality criterion. Existing optimization methods [25, 27] usually are not reliable or cannot use the nondifferentiable, not continuous objective ...
Andrzej Pownuk
doaj
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Method for Semidefinite Quasiconvex Maximization Problem
Известия Иркутского государственного университета: Серия "Математика", 2016 We introduce so-called semidefinite quasiconvex maximization problem. We derive new global optimality conditions by generalizing [9]. Using these conditions, we construct an algorithm which generates a sequence of local maximizers that converges to a ...
R. Enkhbat +3 more
doaj