Results 111 to 120 of about 5,020,641 (311)

English stress preservation and Stratal Optimality Theory [PDF]

open access: yes, 2007
Since Chomsky & Halle (1968), English stress preservation has been important in generative discussions of morphophonological interaction. This thesis carries out empirical investigations into English stress preservation, and uses their results to argue ...
Collie, Sarah
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Intelligent Route Planning for Transport Ship Formations: A Hierarchical Global–Local Optimization and Collaborative Control Framework

open access: yesJournal of Marine Science and Engineering
Multi-vessel formation shipping demonstrates significant potential for enhancing maritime transportation efficiency and economy. However, existing route planning systems inadequately address the unique challenges of formations, where traditional methods ...
Zilong Guo   +5 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Autosegmental spreading in optimality theory

open access: yes, 2011
This paper is a shorter version of ROA-1009 'Harmony in harmonic serialism'. Some material is omitted, but the overall presentation is probably clearer.The publisher of the book in which this excerpt appears does not permit the archiving of this or any ...

core  

Computing Optimal Forms in Optimality Theory: Basic Syllabification

open access: yes, 1995
In Optimality Theory, grammaticality is defined in terms of optimization over a large (often infinite) space of candidates. This raises the question of how grammatical forms might be computed.

core   +1 more source

CAGE: A Curiosity-Driven Graph-Based Explore-Exploit Algorithm for Solving Deterministic Environment MDPs With Limited Episode Problem

open access: yesIEEE Access
The explore-exploit dilemma in Markov Decision Processes (MDPs) is a fundamental challenge, especially in deterministic environments akin to real-world scenarios.
Yide Yu   +5 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Non-computable functions in Optimality Theory

open access: yes, 1999
Is Optimality Theory a constraining theory? A formal analysis shows that it is, if two auxiliary assumptions are made: (1) that only markedness and faithfulness constraints are allowed, and (2) that input and output representations are made from the same

core  

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