Results 51 to 60 of about 30,043 (263)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Modelling and Simulation in Engineering, 2017 An automatic framework for tuning plastic constitutive models is proposed. It is based on multistart global optimisation method, where the objective function is provided by the results of multiple elastoplastic finite element analyses, executed ...
Anton Shterenlikht +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
AgricultureThe greenhouse climate setpoint is an important factor that can affect the energy consumption of greenhouse climate regulation. Therefore, optimising the setpoint is an effective way to save energy.
Yuanping Su, Lihong Xu
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
IET Collaborative Intelligent ManufacturingThe Circulatory System Based Optimisation (CSBO) stands as a nascent metaheuristic optimisation algorithm known for its proficiency in tackling global optimisation problems.
Shiyuan Yang +6 more
doaj +1 more source
Formal Global Optimisation with Taylor Models [PDF]
, 2006 Formal proofs and global optimisation are two research areas that have been heavily influenced by the arrival of computers. This article aims to bring both further together by formalising a global optimisation method based on Taylor models: a set of functions is represented by a polynomial together with an error bound. The algorithms are implemented in
openaire +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Forced convection heat transfer in micro heat sinks with square and circular configuration
Nigerian Journal of Technological Development, 2023 This paper reports the results of three-dimensional numerical optimisation of microchannel heat exchanger with square and circular cooling channels.
Nahum Yustus Godi +2 more
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