Results 71 to 80 of about 30,043 (263)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A General Optimisation‐Based Framework for Global Pose Estimation With Multiple Sensors

IET Cyber-systems and Robotics
Accurate state estimation is a fundamental problem for autonomous robots. To achieve locally accurate and globally drift‐free state estimation, multiple sensors with complementary properties are usually fused together.
Tong Qin, Shaozu Cao, Jie Pan, Shaojie Shen   +3 more
doaj   +1 more source

A novel hybrid biological optimisation algorithm for tackling reservoir optimal operation problem

Ain Shams Engineering Journal
This study introduces the Hybrid Grey-Wolf-Coati Optimiser (HGWCO), a novel metaheuristic algorithm designed for solving constrained optimisation problems.
Xinlong Le, Kang Ling, Liwei Zhou, Yunliang Wen   +3 more
doaj   +1 more source

Topics in Lipschitz global optimisation [PDF]

Bulletin of the Australian Mathematical Society, 1997
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Structural optimisation of oil immersed transformer winding block washers based on WOA‐DRBF surrogate model optimisation strategy

IET Electric Power Applications
In order to reduce the transformer winding hot spot temperature (HST), a dynamic radial basis function surrogate model optimisation strategy is proposed to optimise the structure of the forced oil circulation transformer winding's block washers in this ...
Yufei Dong, Chenglong Gao, Wenxin Xiang, Gang Liu, Yunpeng Liu, Yang Liu, Zhenbin Du   +6 more
doaj   +1 more source

Optimisation Methods for Cold Chain Logistics Path Considering Carbon Emission Costs in Time-Varying Networks

Promet (Zagreb)
With the escalating global climate change, the cost of carbon emissions has become a crucial metric for evaluating the sustainability of logistics systems.
Zeyu WANG, Fujian CHEN, Chengcheng MO
doaj   +1 more source

Haemodynamic optimisation of a dialysis graft design using a global optimisation approach. [PDF]

Int J Numer Method Biomed Eng, 2021
Quicken S, Delhaas T, Mees BME, Huberts W.   +3 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source