Results 91 to 100 of about 1,487,743 (283)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Visual–LiDAR SLAM for Rover Navigation in Planetary Environments With Plane Constraints and Global Optimization

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Planetary rovers are key remote sensing platforms in space exploration, playing a vital role in scene perception and terrain mapping. The safe operation and data acquisition of rovers depend on precise navigation and localization. However, the absence of
Rong Huang, Lingxiao Zhang, Huan Xie, Xiongwen He, Xiong Xu, Changjiang Xiao, Zhen Ye, Yusheng Xu, Xiaohua Tong   +8 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analysis of DRM game control

Tongxin xuebao, 2012
To overcome the limitations of individual rationality,a game control model was proposed.The controller of game is global rational.To achieve global optimization,the controller chooses strategies according to the control goal,and the controlled chooses ...
Guo-jun MA, Qing-qi PEI, Xiao-hong JIANG
doaj  

Advances in Henry Gas Solubility Optimization: A Physics-Inspired Metaheuristic Algorithm With Its Variants and Applications

IEEE Access
The Henry Gas Solubility Optimization (HGSO) is a physics-based metaheuristic inspired by Henry’s law, which describes the solubility of the gas in a liquid under specific pressure conditions. Since its introduction by Hashim et al.
Mohammed A. El-Shorbagy, Anas Bouaouda, Hossam A. Nabwey, Laith Abualigah, Fatma A. Hashim   +4 more
doaj   +1 more source

Global Optimization Using Space Filling Curves

Advances in Electrical and Electronic Engineering, 2017
The existence of space filling curves opens the way to reducing multivariate optimization problems to the minimization of univariate functions. In this paper, we analyze the Hoelder continuity of space filling curves and exploit this property in the ...
Michaela Bailova, Jiri Bouchala, Petr Vodstrcil   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Structures and Properties of MgTiH_n Clusters (n ≤ 20)

Hydrogen
Magnesium hydride solids doped with transition metals have received attention recently as prospective hydrogen storage materials for a green energy source and a hydrogen economy.
Camryn Newland, D. Balamurugan, Jonathan T. Lyon   +2 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Improved Hybrid A* Algorithm Based on Lemming Optimization for Path Planning of Autonomous Vehicles

Applied Sciences
Path planning for autonomous vehicles is a core component of intelligent transportation systems, playing a key role in ensuring driving safety, improving driving efficiency, and optimizing the user experience.
Yong Chen, Yuan Liu, Wei Xu
doaj   +1 more source