Results 91 to 100 of about 6,941,251 (285)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Continuous GRASP with a local active-set method for bound-constrained global optimization

, 2010
Global optimization, Stochastic methods, Active-set methods, Heuristic, CGRASP, GENCAN,
GOZZI, Erico M., Ernesto Birgin, Erico Gozzi, Ricardo Silva, BIRGIN, Ernesto G., RESENDE, Mauricio G. C., Mauricio Resende, SILVA, Ricardo M. A.   +7 more
core   +1 more source

Invasion Percolation and Global Optimization

Physical Review Letters, 1996
4 pages, 3 Postscript figures avaliable from alb@nd.edu ...
openaire   +3 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Visual–LiDAR SLAM for Rover Navigation in Planetary Environments With Plane Constraints and Global Optimization

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Planetary rovers are key remote sensing platforms in space exploration, playing a vital role in scene perception and terrain mapping. The safe operation and data acquisition of rovers depend on precise navigation and localization. However, the absence of
Rong Huang, Lingxiao Zhang, Huan Xie, Xiongwen He, Xiong Xu, Changjiang Xiao, Zhen Ye, Yusheng Xu, Xiaohua Tong   +8 more
doaj   +1 more source

Global Optimization Using Space Filling Curves

Advances in Electrical and Electronic Engineering, 2017
The existence of space filling curves opens the way to reducing multivariate optimization problems to the minimization of univariate functions. In this paper, we analyze the Hoelder continuity of space filling curves and exploit this property in the ...
Michaela Bailova, Jiri Bouchala, Petr Vodstrcil   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysis of DRM game control

Tongxin xuebao, 2012
To overcome the limitations of individual rationality,a game control model was proposed.The controller of game is global rational.To achieve global optimization,the controller chooses strategies according to the control goal,and the controlled chooses ...
Guo-jun MA, Qing-qi PEI, Xiao-hong JIANG
doaj  

Advances in Henry Gas Solubility Optimization: A Physics-Inspired Metaheuristic Algorithm With Its Variants and Applications

IEEE Access
The Henry Gas Solubility Optimization (HGSO) is a physics-based metaheuristic inspired by Henry’s law, which describes the solubility of the gas in a liquid under specific pressure conditions. Since its introduction by Hashim et al.
Mohammed A. El-Shorbagy, Anas Bouaouda, Hossam A. Nabwey, Laith Abualigah, Fatma A. Hashim   +4 more
doaj   +1 more source