Results 41 to 50 of about 1,487,743 (283)

MyThisYourThat for interpretable identification of systematic bias in federated learning for biomedical images

npj Digital Medicine
Distributed collaborative learning is a promising approach for building predictive models for privacy-sensitive biomedical images. Here, several data owners (clients) train a joint model without sharing their original data.
Klavdiia Naumova, Arnout Devos, Sai Praneeth Karimireddy, Martin Jaggi, Mary-Anne Hartley   +4 more
doaj   +1 more source

Machine Learning in Quasi-Newton Methods

Axioms
In this article, we consider the correction of metric matrices in quasi-Newton methods (QNM) from the perspective of machine learning theory. Based on training information for estimating the matrix of the second derivatives of a function, we formulate a ...
Vladimir Krutikov, Elena Tovbis, Predrag Stanimirović, Lev Kazakovtsev, Darjan Karabašević   +4 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

A Procedure of Global Optimization and its Application to Estimate Parameters in Interaction Spatial Models [PDF]

International Journal for Simulation and Multidisciplinary Design Optimization, 2010
This work concerns the calibration of trip distribution models issued from Transportation Planning. The optimal estimators are the global minima of a non-convex function.
Bez Edson Tadeu, Gonçalves Mirian Buss, Souza de Cursi José Eduardo   +2 more
doaj   +1 more source

Validation of a model of regulation in the tryptophan operon against multiple experiment data using global optimisation [PDF]

, 2009
This paper is concerned with validating a mathematical model of regulation in the tryptophan operon using global optimization. Although a number of models for this biochemical network are proposed, in many cases only qualitative agreement between the ...
Bates, D.G., Heslop-Harrison, P., Kim, J.-R., Kim, J.-S., Postlethwaite, I.   +4 more
core  

Adaptive hybrid optimization strategy for calibration and parameter estimation of physical models

, 2011
A new adaptive hybrid optimization strategy, entitled squads, is proposed for complex inverse analysis of computationally intensive physical models. The new strategy is designed to be computationally efficient and robust in identification of the global ...
Atmadji, Carrera, Clerc, Cooren, Dahlin, Dawkins, Digalakis, Dokou, Dylan R. Harp, Ghaffari-Miab, Griewank, Harp, Jessell, Krasnogor, Lagarias, Levenberg, Locatelli, Marquardt, Meek, Moscato, Nelder, Nocedal, Pan, Poeter, Poeter, Rao, Rosenbrock, Shang, Snodgrass, Sun, Velimir V. Vesselinov, Vesselinov, Vrugt, Wang, Wilson, Zhang   +35 more
core   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Experimental Study of Excessive Local Refinement Reduction Techniques for Global Optimization DIRECT-Type Algorithms

Mathematics, 2022
This article considers a box-constrained global optimization problem for Lipschitz continuous functions with an unknown Lipschitz constant. The well-known derivative-free global search algorithm DIRECT (DIvide RECTangle) is a promising approach for such ...
Linas Stripinis, Remigijus Paulavičius
doaj   +1 more source

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source