Results 101 to 110 of about 286,749 (305)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
APPLICATION OF HYBRID RANDOM SEARCH METHOD TO OPTIMISATION OF ENGINEERING SYSTEMS’ PARAMETERS
Научный вестник МГТУ ГА, 2018 This paper presents a modification of the Luus-Jaakola global optimization method, which belongs to the class of metaheuristic algorithms. A hybrid method is suggested, using a combination of random search methods: Luus-Jaakola method, adaptive random ...
A. V. Panteleev, D. A. Rodionova
doaj +1 more source
Global optimality conditions and optimization methods for quadratic integer programming problems
, 2011 Global optimality conditions, Quadratic integer programming problem, Optimization method, Auxiliary function, 41A65, 41A29, 90C30,
Wu, Zhiyou +7 more
core +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
International Journal of Distributed Sensor Networks, 2015 The idea of network protocol design based on optimization theory has been proposed and used practically in Internet for about 15 years. However, for large-scale wireless ad hoc network, although protocol could be viewed as a recursive solving of a global
Chaonong Xu +3 more
doaj +1 more source
Global Optimization by Particle Swarm Method:A Fortran Program
Programs that work very well in optimizing convex functions very often perform poorly when the problem has multiple local minima or maxima. They are often caught or trapped in the local minima/maxima.
Mishra, SK
core
Box-constrained vector optimization: a steepest descent method without “a priori” scalarization [PDF]
In this paper a notion of descent direction for a vector function defined on a box is introduced. This concept is based on an appropriate convex combination of the “projected” gradients of the components of the objective functions.
Miglierina Enrico +2 more
core