Results 91 to 100 of about 286,749 (305)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Minorant methods for stochastic global optimization
, 2005 We develop numerical methods for solution of stochastic global optimization problems: min$[F(x)=Ef(x,¦Ø)| xin X]$ and $min[F(x)=P{f(x, ¦Ø) ¡Ü0} | xin X]$, where x is a finite dimensional decision vector with possible values in the set X, ¦Ø is a random variable, $f(x,¦Ø)$ is a nonlinear function of variable x, E and P ...
Norkin, Vladimir, Onischenko, Boris.
openaire +4 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Advances in Mechanical Engineering, 2017 For a seamless two-speed transmission specially equipped in electric vehicles, the global trajectory optimization problem of the overlapping shift process with multiple stages and complex path/point constraints is investigated in this article.
Jie Ye +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Application of the Parabola Method in Nonconvex Optimization
AlgorithmsWe consider the Golden Section and Parabola Methods for solving univariate optimization problems. For multivariate problems, we use these methods as line search procedures in combination with well-known zero-order methods such as the coordinate descent ...
Anton Kolosnitsyn +3 more
doaj +1 more source
Global optimization of bounded factorable functions with discontinuities
, 2016 A deterministic global optimization method is developed for a class of discontinuous functions. McCormick’s method to obtain relaxations of nonconvex functions is extended to discontinuous factorable functions by representing a discontinuity with a step ...
Barton, Paul I., Wechsung, Achim
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Shape optimization with the biological growth method: A parameter study
, 1996 Studies the effect of parameters controlling the biological growth method by applying it to the classical optimization problem of a plate with a central hole under biaxial stress state.
Guneri, A, Tekkaya, AE
core +1 more source