Results 71 to 80 of about 286,749 (305)

Adaptive management and multi-objective optimization of virtual machine in cloud computing based on particle swarm optimization

EURASIP Journal on Wireless Communications and Networking, 2020
In order to improve the adaptive management ability of virtual machine placement in cloud computing, an adaptive management and multi-objective optimization method for virtual machine placement in cloud computing is proposed based on particle swarm ...
Shuxiang Li, Xianbing Pan
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

High-quality binary fringe patterns generation by combining optimization on global and local similarity

Journal of the European Optical Society-Rapid Publications, 2018
Background The recently proposed optimized dithering techniques can improve measurement quality. However, the objective function in these optimization methods just qualifies the global similarity of the pattern while the global optimization methods ...
Feng Lu, Chengdong Wu, Jikun Yang
doaj   +1 more source

Search space pruning and global optimization of multiple gravity assist trajectories with deep space manoeuvres

, 2007
This paper deals with the design of optimal multiple gravity assist trajectories with deep space manoeuvres. A pruning method which considers the sequential nature of the problem is presented.
M. Ceriotti, Becerra, Victor M., Nasuto, S. J., Nasuto, S.J., C. Bombardelli, Anderson, J., Bombardelli, C., Ceriotti, M., Anderson, James D., Becerra, V.M., Nasuto, Slawomir J., V.M. Becerra, Becerra, V. M., S.J. Nasuto, J. Anderson, Bombardelli, Claudio   +15 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

COMPLEX METHOD OF SEEKING THE MAXIMUM OF NON-NEGATIVE FUNCTION OF TWO VARIABLES

Jixie qiangdu, 2018
The optimization problems of binary functions widely exist in many practical engineering problems,their global optimization methods have always been one of the hot research issues.
ZHANG Jing, SHI WenPu
doaj  

New technique for solving univariate global optimization [PDF]

, 2017
summary:In this paper, a new global optimization method is proposed for an optimization problem with twice differentiable objective function a single variable with box constraint. The method employs a difference of linear interpolant of the objective and
Noui, Amel, Ouanes, Mohand, Djamel Aaid, Amel Noui, Aaid, Djamel, Mohand Ouanes   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A two-level global optimization method based on hybrid metamodel for expensive problems

Advances in Mechanical Engineering, 2018
With the wide application of simulation and optimization tools in engineering problems, how to build a metamodel, which can satisfy the high accuracy requirements of real working conditions and realize fast optimization in the entire design space ...
Renjie Ran, Wenqiang Li, Yan Li
doaj   +1 more source