Results 51 to 60 of about 286,749 (305)
Local optimization method with global multidimensional search
, 2005 This paper presents a new method for solving global optimization problems. We use a local technique based on the notion of discrete gradients for finding a cone of descent directions and then we use a global cutting angle algorithm for finding global ...
Zhang, Jiapu +2 more
core +1 more source
Multidisciplinary design optimization framework for the pre design stage [PDF]
, 2010 Presented is a novel framework for performing flexible computational design studies at preliminary design stage. It incorporates a workflow management device (WMD) and a number of advanced numerical treatments, including multi-objective optimization ...
Balachandran, Libish Kalathil +11 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Hybrid Lightning Search Algorithm-Simplex Method for Global Optimization
Discrete Dynamics in Nature and Society, 2017 In this paper, a novel hybrid lightning search algorithm-simplex method (LSA-SM) is proposed to solve the shortcomings of lightning search algorithm (LSA) premature convergence and low computational accuracy and it is applied to function optimization and
Yuting Lu, Yongquan Zhou, Xiuli Wu
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
A CARTopt method for bound constrained global optimization [PDF]
ANZIAM Journal, 2013 AbstractA stochastic algorithm for bound-constrained global optimization is described. The method can be applied to objective functions that are nonsmooth or even discontinuous. The algorithm forms a partition on the search region using classification and regression trees (CART), which defines a region where the objective function is relatively low ...
Robertson, B.L., Price, C.J., Reale, M.
openaire +3 more sources
IEEE Access, 2022 This paper presents a novel multi-material topology optimization method for electric motors. In the proposed method, the search process is divided into two steps.
Yuki Hidaka
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
A Combined Optimization Method for the Transition Control Schedules of Aero-Engines
AerospaceA well designed transition control schedule can enable the engine to quickly and smoothly transition from one operating state to another, thereby enhancing the maneuverability of the aircraft.
Wang Hao +4 more
doaj +1 more source
Continuous GRASP with a local active-set method for bound-constrained global optimization
, 2010 Global optimization, Stochastic methods, Active-set methods, Heuristic, CGRASP, GENCAN,
GOZZI, Erico M. +7 more
core +1 more source