Results 41 to 50 of about 286,749 (305)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

HIGH SPEED FUNCTIONALITY OPTIMIZATION OF FIVE-PHASE PM MACHINE USING 3RD HARMONIC CURRENT [PDF]

open access: yes, 2013
This project was supported by the Laboratory of Electrical Engineering and Power Electronics (L2EP) France. It is a successive cooperation project between the control team and optimization team of the laboratory .Some surrogate-assisted optimization ...
GONG, Jinlin   +4 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

PSO Algorithm Particle Filters for Improving the Performance of Lane Detection and Tracking Systems in Difficult Roads

open access: yesSensors, 2012
In this paper we propose a robust lane detection and tracking method by combining particle filters with the particle swarm optimization method. This method mainly uses the particle filters to detect and track the local optimum of the lane model in the ...
Wen-Chang Cheng
doaj   +1 more source

On the design of optimization strategies based on global response surface approximation models

open access: yes, 2005
Striking the correct balance between global exploration of search spaces and local exploitation of promising basins of attraction is one of the principal concerns in the design of global optimization algorithms.
András Sóbester   +5 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A hybrid method for solving multi-objective global optimization problems

open access: yes, 2007
Real optimization problems often involve not one, but multiple objectives, usually in conflict. In single-objective optimization there exists a global optimum, while in the multi-objective case no optimal solution is clearly defined but rather a set of ...
Gómez López, Julio   +4 more
core   +1 more source

A Scalarizing One-Stage Algorithm for Efficient Multi-Objective Optimization [PDF]

open access: yes, 2007
A novel kriging-assisted algorithm is proposed for computationally expensive multi-objective optimization problems, such as those which arise in electromagnetic design. The algorithm combines the multiple objectives into a single objective, which it then
Hawe, G. I.   +3 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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