Results 111 to 120 of about 7,934,994 (308)

A Workflow for Global Sensitivity Analysis of PBPK Models

Frontiers in Pharmacology, 2011
Physiologically based pharmacokinetic models have a potentially significant role in the development of a reliable predictive toxicity testing strategy. The structure of PBPK models are ideal frameworks into which disparate in vitro and in vivo data can ...
Kevin eMcNally, Richard eCotton, George D Loizou   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Global Health Security Branch : advancing global health security [PDF]

The Global Health Security Branch (GHSB) leads CDC\ue2\u20ac\u2122s global health security engagement with other U.S. government agencies and programs, multilateral institutions such as the World Health Organization (WHO) and the World Bank, ministries ...

core  

Sensitivity Maps in Environmental Impact Studies [PDF]

, 2014
Environmental Sensitivity is closely linked to the concepts of reception or absorption recovery that have environmental components such capabilities must be addressed in a holistic and integrated for analysis of constructive alternatives to incorporate
Virgilio NAAez
core  

Technical note: Machine learning metamodelling for global sensitivity analysis [PDF]

Hydrology and Earth System Sciences
Global sensitivity analysis (GSA) plays a central role in hydrologic modelling by supporting model understanding, diagnosis, and decision-making through the identification of influential and non-influential parameters and their interactions.
P. Yeste, P. Yeste, P. Yeste, L. A. Melsen, J. P. L. F. Brêda, N. Tacoronte, A. Saltelli, A. Saltelli, G. Vannucci, R. Siciliano, A. Bronstert   +10 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The Global Phenomenon of Self-Reported Wheat Sensitivity [PDF]

American Journal of Gastroenterology, 2018
Celiac disease affects about 1% of the population and is treated with a gluten-free diet. However, the last decade has seen a huge rise in individuals self-reporting wheat sensitivity, and consuming a gluten-free diet, despite not having a doctor-diagnosis of celiac disease.
openaire   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Design of an integral sliding mode controller for reducing CO2 emissions in the transport sector to control global warming

Scientific Reports
Carbon dioxide (CO2) is the significant contributor to greenhouse gases and plays a crucial role in the greenhouse effect and climate change. The primary source of CO2 emissions is fossil fuel combustion, basically due to human activities and ...
Abid Mehmood, Mohsan Hassan, Pita Donald, Mohammed M. A. Almazah   +3 more
doaj   +1 more source