Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity
FEBS Open Bio, EarlyView.This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang +6 more
wiley +1 more source
Global Sensitivity Analysis of Four Chamber Heart Hemodynamics Using Surrogate Models. [PDF]
IEEE Trans Biomed Eng, 2022 Karabelas E +9 more
europepmc +1 more source
Toward a more robust variance-based global sensitivity analysis of model outputs
, 2007 Charles Tong
openalex +2 more sources
FEBS Open Bio, EarlyView.TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo +11 more
wiley +1 more source
FBA-PRCC. Partial Rank Correlation Coefficient (PRCC) Global Sensitivity Analysis (GSA) in Application to Constraint-Based Models. [PDF]
Biomolecules, 2023 Sorokin A, Goryanin I.
europepmc +1 more source
FEBS Open Bio, EarlyView.Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr +5 more
wiley +1 more source
Multivariate global sensitivity analysis for dynamic crop models
, 2009 Matieyendou Lamboni +4 more
openalex +2 more sources
Global Sensitivity Analysis of a Physiologically-based Pharmacokinetic (PBPK) Model of Bromochloromethane [PDF]
, 2020 Sawyer, Colton
core +1 more source
High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer
FEBS Open Bio, EarlyView.Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson +5 more
wiley +1 more source
Investigating Bayesian Robust Experimental Design with Principles of Global Sensitivity Analysis
, 2010 Fei He, Hong Yue, Martin Brown
openalex +1 more source