Results 51 to 60 of about 2,416,289 (329)

Asymptotic Analysis for the Variance-Based Global Sensitivity Indices

Science and Technology of Nuclear Installations, 2012
We discuss the estimation of the uncertainty and sensitivity parameters for a model response under the assumption that the input variables are normally distributed and block-wise correlated with the covariance matrix, which is small in some norm.
Pavel M. Bokov
doaj   +1 more source

Lifestyle Behaviors and Cardiotoxic Treatment Risks in Adult Childhood Cancer Survivors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Higher doses of anthracyclines and heart‐relevant radiotherapy increase cardiovascular disease (CVD) risk. This study assessed CVD and CVD risk factors among adult childhood cancer survivors (CCSs) across cardiotoxic treatment risk groups and examined associations between lifestyle behaviors and treatment risks.
Ruijie Li, Raquel Revuelta Iniesta, Alan R. Barker, Dimitris Vlachopoulos, Tomáš Sláma, Christina Schindera, Fabiën N. Belle   +6 more
wiley   +1 more source

Global Sensitivity Analysis and Uncertainty Quantification for Simulated Atrial Electrocardiograms

Metrology, 2022
The numerical modeling of cardiac electrophysiology has reached a mature and advanced state that allows for quantitative modeling of many clinically relevant processes.
Benjamin Winkler, Claudia Nagel, Nando Farchmin, Sebastian Heidenreich, Axel Loewe, Olaf Dössel, Markus Bär   +6 more
doaj   +1 more source

Pricing and Risk Management with High-Dimensional Quasi Monte Carlo and Global Sensitivity Analysis

, 2015
We review and apply Quasi Monte Carlo (QMC) and Global Sensitivity Analysis (GSA) techniques to pricing and risk management (greeks) of representative financial instruments of increasing complexity.
Bianchetti, Marco, Kucherenko, Sergei, Scoleri, Stefano   +2 more
core   +1 more source

A Review on Global Sensitivity Analysis Methods [PDF]

, 2015
This chapter makes a review, in a complete methodological framework, of various global sensitivity analysis methods of model output. Numerous statistical and probabilistic tools (regression, smoothing, tests, statistical learning, Monte Carlo, \ldots) aim at determining the model input variables which mostly contribute to an interest quantity depending
Iooss, Bertrand, Lemaître, Paul
openaire   +3 more sources

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Design of an integral sliding mode controller for reducing CO2 emissions in the transport sector to control global warming

Scientific Reports
Carbon dioxide (CO2) is the significant contributor to greenhouse gases and plays a crucial role in the greenhouse effect and climate change. The primary source of CO2 emissions is fossil fuel combustion, basically due to human activities and ...
Abid Mehmood, Mohsan Hassan, Pita Donald, Mohammed M. A. Almazah   +3 more
doaj   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

A Systematic Review of Evidence on the Clinical Effectiveness of Surveillance Imaging in Children With Medulloblastoma and Ependymoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Surveillance imaging aims to detect tumour relapse before symptoms develop, but it's unclear whether earlier detection of relapse leads to better outcomes in children and young people (CYP) with medulloblastoma and ependymoma. This systematic review aims to identify relevant literature to determine the efficacy of surveillance magnetic ...
Lucy Shepherd, Melissa Taylor, Helen Fulbright, Bob Phillips   +3 more
wiley   +1 more source

A Workflow for Global Sensitivity Analysis of PBPK Models

Frontiers in Pharmacology, 2011
Physiologically based pharmacokinetic models have a potentially significant role in the development of a reliable predictive toxicity testing strategy. The structure of PBPK models are ideal frameworks into which disparate in vitro and in vivo data can ...
Kevin eMcNally, Richard eCotton, George D Loizou   +2 more
doaj   +1 more source