Results 51 to 60 of about 880,355 (265)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Toponymy and Branding of Modern Residential Sites in Semarang

E3S Web of Conferences, 2018
This study concerns with the phenomenon of naming residential areas using both local and foreign language and choosing lexicons relating to nature. Using critical toponymy and critical discourse analysis, 53 names were analyzed.
Nurhayati Nurhayati
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Merging the Common Outlines of Globalization, Education and Business for Shared Values: An Analytical Approach and a Case Study [PDF]

Ovidius University Annals: Economic Sciences Series
This paper presents the mutual mechanism of “Globalization, Education and Business” and how possible and important it is for the three phenomena.
Anis Benabed , Oana Voiculet
doaj  

Using Behavioral Science to end the Tropical Forest Wild Meat Crisis, illustrated by a case example from Central Africa

Conservation Science and Practice
In tropical forests today, hunting for food and income remains largely unsustainable, with adverse implications for biodiversity, ecological services, and human wellbeing.
David S. Wilkie, John G. Robinson, Elizabeth L. Bennett, The WCS Wild meat Group   +3 more
doaj   +1 more source

Flexible Citizenship for a Global Society [PDF]

SSRN Electronic Journal, 2001
States are ill equipped to meet the challenges of a globalized world. The concept of citizenship with its rights and obligations, including the allegiance owed, is too narrowly defined to exist only between individuals and a state. Today, people identify with, and pay allegiance to, many organizations beyond the state.
openaire   +7 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Elevated liver enzyme (AST and ALT) as biomarkers for severe dengue in Nepalese patients: a cross-sectional study

BMC Infectious Diseases
Introduction Dengue remains a major global health concern, with rising incidence and severity in endemic regions. Liver involvement, particularly elevated transaminases such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT), is ...
Chandramani Wagle, Dinesh Prasad Ghimire, Ajay Kumar Sah, Abhay Kumar Sah, Vivek Prasad Gupta, Surendra Uranw, Birendra Prasad Gupta   +6 more
doaj   +1 more source