Results 91 to 100 of about 798,781 (261)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Blowup and existence of global solutions to nonlinear parabolic equations with degenerate diffusion
Electronic Journal of Differential Equations, 2013 In this article, we consider the degenerate parabolic equation $$ u_t-\hbox{div}(|\nabla u|^{p-2}\nabla u) =\lambda u^m+\mu|\nabla u|^q $$ on a smoothly bounded domain $\Omega\subseteq\mathbb{R}^N\; (N\geq2)$, with homogeneous Dirichlet boundary ...
Zhengce Zhang, Yan Li
doaj
The movement of multidrug-resistant tuberculosis across borders in East Africa needs a regional and global solution. [PDF]
PLoS Med, 2015 Cain KP +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Nonexistence of positive global solutions to the differential equation $u''(t)-t^{-p-1} u^{p}=0$
Electronic Journal of Differential Equations, 2016 A blow-up result for positive solutions to the differential equation $u''(t)-t^{-p-1} u^{p}=0$ is derived. Our result is different from the one obtained in the [1], and our conditions are less restrictive.
Ahmed Alsaedi, Bashir Ahmad
doaj
Demonstratio MathematicaThe aim of this work is to study the global existence in time of solutions for the tridiagonal system of reaction-diffusion by order mm. Our techniques of proof are based on compact semigroup methods and some L1{L}^{1}-estimates.
Barrouk Nabila, Abdelmalek Karima
doaj +1 more source
Dynamics of Hepatitis B Virus Transmission with a Lévy Process and Vaccination Effects
MathematicsThis work proposes a novel stochastic model describing the propagation dynamics of the hepatitis B virus. The model takes into account numerous disease characteristics, and environmental disturbances were collected using Lévy jumps and the conventional ...
Sayed Murad Ali Shah +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source