Results 71 to 80 of about 798,781 (261)

Analyticity and Existence of the Keller–Segel–Navier–Stokes Equations in Critical Besov Spaces

Advanced Nonlinear Studies, 2018
This paper deals with the Cauchy problem to the Keller–Segel model coupled with the incompressible 3-D Navier–Stokes equations. Based on so-called Gevrey regularity estimates, which are motivated by the works of Foias and Temam [20], we prove that the ...
Yang Minghua, Fu Zunwei, Liu Suying
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Existence and continuation of solutions for Caputo type fractional differential equations

Electronic Journal of Differential Equations, 2016
In this article, we consider a fractional differential equation (FDE) with Caputo derivative and study the existence and continuation of its solution. Firstly, we prove a theorem on the existence of local solutions.
Changpin Li, Shahzad Sarwar
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Secret level valuation method of BLP model based on some application properties

Tongxin xuebao, 2013
According to the access attribute properties between subjects and objects in the information system,a viable method of the BLP model secret level valuation was given,and two merging conditions were put forward.The mathematical model of subject-object ...
Chan DONG, Xiu-bin FAN, You-wen LI, Jian-rong WANG   +3 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Global well-posedness of semilinear hyperbolic equations, parabolic equations and Schrodinger equations

Electronic Journal of Differential Equations, 2018
This article studies the existence and nonexistence of global solutions to the initial boundary value problems for semilinear wave and heat equation, and for Cauchy problem of nonlinear Schrodinger equation.
Runzhang Xu, Yuxuan Chen, Yanbing Yang, Shaohua Chen, Jihong Shen   +4 more
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