Results 161 to 170 of about 947,098 (315)
Pullback attractors for non-autonomous parabolic equations involving Grushin operators
Electronic Journal of Differential Equations, 2010 Using the asymptotic a priori estimate method, we prove the existence of pullback attractors for a non-autonomous semilinear degenerate parabolic equation involving the Grushin operator in a bounded domain.
Cung The Anh
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Dynamical behavior in a reaction-diffusion system with prey-taxis
Electronic Journal of Differential Equations, 2022 Yingwei Song, Tie Zhang, Jinpeng Li
doaj
GLOBAL SOLUTIONS FOR GLOBAL PROBLEMS
, 2009 Governments are implementing fiscal and monetary flexibility to reverse the negative effects of global crisis, but the results are sterile or minimal. Despite that injected billions of dollars to save their financial operations, multinational corporations continue to show signs of economic deterioration, so much so that flagship companies in the world ...
openaire +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Fully Well-Balanced Methods for Schwarzschild-Euler Equation in Gullstrand-Painlevé Coordinates. [PDF]
J Sci ComputPimentel-García E +3 more
europepmc +1 more source