Results 51 to 60 of about 782,077 (262)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nonexistence of global solutions for differential inequalities of Sobolev type
Electronic Journal of Differential Equations, 2014 In this article we study three differential inequalities of Sobolev type. Using Pokhozhaev's nonlinear capacity method, we provide sufficient conditions for the nonexistence of global nontrivial weak solutions to these problems.
Mohamed Jleli, Bessem Samet
doaj
Long time decay of incompressible convective Brinkman-Forchheimer in L2(ℝ3)
Demonstratio MathematicaIn this article, we study the global existence, uniqueness, and continuity for the solution of incompressible convective Brinkman-Forchheimer on the whole space R3{{\mathbb{R}}}^{3} when 4μβ≥14\mu \beta \ge 1.
Jlali Lotfi, Benameur Jamel
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Nonlinear quarter-plane problem for the Korteweg-de Vries equation
Electronic Journal of Differential Equations, 2011 This article concerns an initial-boundary value problem in a quarter-plane for the Korteweg-de Vries (KdV) equation. For general nonlinear boundary conditions we prove the existence and uniqueness of a global regular solution.
Nikolai A. Larkin, Eduardo Tronco
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Generalized spreading speeds for lattice differential equations with time and space dependence
Electronic Journal of Differential Equations, 2019 This article concerns the spatial spreading speeds for lattice differential equations with general time and space dependence. Firstly, we give the concept of spreading speed intervals.
Ning Wang, Zhi-Cheng Wang
doaj
Electronic Journal of Differential Equations, 2020 This article concerns a two-dimensional Keller-Segel-Navier-Stokes system with porous medium diffusion and rotational flux describing the coral fertilization.
Lingzhu Wang, Li Xie
doaj