Results 91 to 100 of about 1,755,386 (294)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Mapping global value chains at the product level
EPJ Data ScienceValue chain data is crucial for navigating economic disruptions. Yet, despite its importance, we lack publicly available product-level value chain datasets, since resources such as the “World Input-Output Database”, “Inter-Country Input-Output Tables ...
Lea Karbevska, César A. Hidalgo
doaj +1 more source
The Role of Inter-Organizational Leadership in Agri-Food Value Chains [PDF]
For many years research on marketing channel behaviour was focused on power and conflict between channel members. More recently, as a result of globalisation, firms have become more dependent on each other and more collaborative models of channel ...
Dooley, Lawrence B., Luca, E.
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Crisis and protection in the automotive industry : a global value chain perspective [PDF]
In this paper the authors apply global value chain (GVC) analysis to recent trends in the global automotive industry, with special attention paid to government interventions triggered by the recent economic crisis. The authors first highlight some of the
Sturgeon, Timothy J. +1 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Agriculture[Objective] Digital infrastructure, with its fundamental and public good characteristics, can have a significant impact on export trade. This paper aims to analyze the impact and mechanism of digital infrastructure construction on the added value of ...
Yutian Zhang, Linyan Ma, Feng Wei
doaj +1 more source
Performance Improvements through Implementation of Lean Practices: A Study of the U.K. Red Meat Industry [PDF]
'Lean' is an established industrial paradigm with proven track record in various sectors of the industry (Womack & Jones, 1996). World-class Companies such as Toyota (second biggest global car manufacturer), Porsche (most profitable global OEM), Boeing ...
Simons, David, Zokaei, Keivan
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
The Global Value Chain in Coronavirus Era: An Impact Approach [PDF]
Romanian Economic Journal, 2020 Global Value Chains (GVC) play a particular role in the mechanisms of world economy and any disruption of them has strong unwanted consequences on their operation. Our research aims to identify and characterize the negative impact of COVID-19 on GVCs and,
Victor Danciu
doaj