Results 71 to 80 of about 511,014 (306)

Energy and environmental burdens of organic and non-organic agriculture and horticulture [PDF]

, 2006
Production of 10 major commodities in England and Wales was studied using Life Cycle Analysis (LCA). Organic and non-organic (contemporary conventional) systems were compared.
Audsley, E, Sandars, D L, Williams, A G
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Biomethane in Brazilian light commercial vehicles: a case study in performance, emissions, GT-SUITE simulations and life cycle assessment

Case Studies in Thermal Engineering
Biomethane is a renewable alternative to natural gas with strong potential to reduce greenhouse gas emissions in transportation. This study evaluates its application in Brazilian light commercial vehicles through experimental testing, GT-SUITE simulation,
Luis Filipe de Almeida Roque, Roberto Berlini Rodrigues da Costa, Rafael Silva Capaz, Douglas Peterson Munis da Silva, Luís Pedro Vieira Vidigal, Túlio Augusto Zucareli de Souza, Gustavo Vieira Frez, Nelly Vanessa Pérez Rangel, Gabriel Marques Pinto, Davi José Souza Ferreira, Christian Jeremi Rodriguez Coronado   +10 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Improving thermal conductivity of fired clay brick using sawdust waste [PDF]

, 2018
The demand for energy efficient design and construction has become progressively important with the growing energy costs and increasing awareness on the effects of global warming.
Abas, Nor Haslinda, Abdullah, Abd Halid bin, Deraman, Rafikullah, Hasmori, Mohd Fikri, Nagapan, Sasitharan, Suratkon, Azeanita Binti   +5 more
core   +1 more source

Global warming potential for CF[sub 4]

, 1992
With sufficient emissions, fluorinated gases such as CF[sub 4] could contribute significantly to the concerns about global warming because they are greenhouse gases, are chemically very inert, and have long accumulation lifetimes in the atmosphere. At this time, the only significant known source of CF[sub 4] is primary aluminum smelting (Abrahamson ...
D Wuebbles, A Grossman
openaire   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Metrics for aggregating the climate effect of different emissions: A unifying framework [PDF]

, 2008
Multi-gas approaches to climate change policies require a metric establishing equivalences among emissions of various species. Climate scientists and economists have proposed four classes of such metrics and debated their relative merits.
Balkanski, Yves, Berntsen, Terje K., Fuglestvedt, Jan S., Makra, Laszlo, O'Neill, Brian C., Shine, Keith P., Tol, Richard S. J.   +6 more
core  

Ice sheets as a significant source of highly reactive nanoparticulate iron to the oceans [PDF]

, 2014
The Greenland and Antarctic Ice Sheets cover ~\n10% of global land surface, but are rarely considered as active components of the global iron cycle. The ocean waters around both ice sheets harbour highly productive coastal ecosystems, many of which are ...
Benning, Liane G., Hawkings, Jon R., Lee, Katherine, Nienow, Peter, Raiswell, Rob, Statham, Peter J., Tedstone, Andrew, Telling, Jon, Tranter, Martyn, Wadham, Jemma L.   +9 more
core   +2 more sources