Results 91 to 100 of about 125,612 (305)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Globalisation and rural development in Africa: the case of the Chad-Cameroon oil pipeline [PDF]

open access: yes, 2006
The process of globalisation is multifaceted. One is smiling and promising, the other looks less attractive, if not threatening. It is the process of growing interdependence of countries worldwide through the increasing volume of cross-border ...
Sikod, Fondo
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Higher education in the era of globalisation [PDF]

open access: yes, 2014
The article will analyse the impact of globalisation on higher education. Some have argued that globalisation will provide equal opportunities. While others claim that globalisation would mean the McDonaldisation of the university and also worldwide ...
Siddiqui, Kalim
core   +2 more sources

Stay behind children's differential educational performance: The impact of parental migration arrangements in China

open access: yesInternational Journal of Educational Research Open
Millions of children live apart from their parents who migrate for work. This dynamic raises questions about parental migration's impact on children's schooling. This paper investigated how Chinese junior high school students’ educational performance was
Jiancheng Gu
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

The Rational Expectations in Globalisation: Gauged Globalisation

open access: yesFOCUS: Journal of International Business, 2018
The forward march of globalisation seems muted since the financial crisis of 2008. Literature shows globalisation entering a more cautious and regulated phase. We‟re creating a “a new gated globalisation” argues Greg (2013). According to him, „walls have been constructed‟ to obstruct the free flow of trade and money.
Binish Qadri   +2 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

The Risks and Opportunities from Globalisation [PDF]

open access: yes
Globalisation, being the trend towards increasing global economic integration, is one of the largest forces, if not the largest force, affecting world economies at present.
Wayne Stevens
core  

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