Results 91 to 100 of about 77,983 (316)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Ouverture de ‘Innovation Management in Global Markets – 1’
Symphonya, 2012 Since the 80s, given the markets globalisation springing up (product globalisation), the ‘core activity’ of R&D was focused on corporate internal structures.
Silvio M. Brondoni
doaj +1 more source
Determining Factors of Economy Globalisation [PDF]
Approached from an economic and financial point of view, globalisation can be defined as strengthening and widening the connections between the national economies on the global market of goods, services and especially the capitals.
Mirela Mazilu
core
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Higher education in the era of globalisation
, 2014 The article will analyse the impact of globalisation on higher education. Some have argued that globalisation will provide equal opportunities. While others claim that globalisation would mean the McDonaldisation of the university and also worldwide ...
Siddiqui, Kalim
core
Women Reinventing Globalisation [PDF]
, 2003 Women Reinventing Globalisation is a collection of articles drawn from the Association for Women's Rights in Development (AWID)'s Ninth International Forum, on this subject.
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The discourse of globalisation and the logic of no alternative : rendering the contingent necessary in the political economy of New Labour [PDF]
, 2003 Although convincingly discredited academically, a crude 'business school' globalisation thesis of a single world market, with its attendant political 'logic of no alternative', continues to dominate the discourse of globalisation adopted by the British ...
Hay, Colin, Watson, Matthew
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source