Results 171 to 180 of about 7,450 (200)

Interfering parameters in the determination of urinary globotriaosylceramide (Gb3) in patients with chronic kidney disease

Journal of Nephrology, 2015
Globotriaosylceramide (Gb3, CD77) represents a pivotal part of the cell membrane. Measuring the urinary Gb3 content can be used to screen patients with chronic kidney disease (CKD) for Fabry disease, a disorder caused by hampered Gb3 degradation. However, little is known about factors influencing urinary Gb3 excretion other than Fabry disease.
Martina Gaggl, Marlene Hofer, Stefanie Weidner, Julia Kleinert, Günter Fauler, Manfred Wallner, Peter Kotanko, Eduard Paschke, Gere Sunder‐Plassmann   +8 more
semanticscholar   +4 more sources

Evaluation of the urinary globotriaosylceramide (Gb3) assay by tandem mass spectrometry

Molecular & Cellular Toxicology, 2010
Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from a deficiency of α-galactosidase A, which leads to the progressive accumulation of one biomarker, globotriaosylceramide (Gb3), prominently elevated in the urine of affected patients.
Minjung Song, Ok-Ja Ji, Hyung‐Doo Park, Dong‐Kyu Jin, Soo‐Youn Lee   +4 more
semanticscholar   +3 more sources

Modelling of the interaction of verotoxin-1 (VT1) with its glycolipid receptor, globotriaosylceramide (Gb3)

International Journal of Biological Macromolecules, 1995
Possible binding sites for the glycolipid globotriaosylceramide (Gal alpha 1-->4Gal beta 1-->4Glc beta 1-->1 Cer; Gb3) on the B-subunits of verotoxin-1 (VT1) were explored using binding data for specifically mutated verotoxins and by computational docking of favoured conformers of Gb3 with the crystal structure of VT1.
Per‐Georg Nyholm, James Brunton, Clifford A. Lingwood   +2 more
semanticscholar   +4 more sources

ChemInform Abstract: Glycosyl Imidates. Part 52. Synthesis of Globotriaosylceramide (Gb3) and Isoglobotriaosylceramide (isoGb3).

ChemInform, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dongxu Qiu, Richard R. Schmidt
semanticscholar   +3 more sources

An easy and sensitive method for determination of globotriaosylceramide (Gb3) from urinary sediment: Utility for Fabry disease diagnosis and treatment monitoring

Clinica Chimica Acta, 2009
Fabry disease is an X-linked disorder that results from the deficiency of the lysosomal enzyme alpha-galactosidase A. The defect leads to the accumulation of globotriaosylceramide (Gb3). The detection of Gb3 accumulated in different tissues may help in the diagnosis and enzyme replacement therapy monitoring.
Paula Rozenfeld, Pablo N. De Francesco, Gustavo Borrajo, Romina Ceci, Carlos A. Fossati   +4 more
semanticscholar   +4 more sources

Efficacy of targeted nanoliposomes in reducing globotriaosylceramide (Gb3) accumulation in mouse models of Fabry disease

Molecular Genetics and Metabolism, 2022
Marc Moltó‐Abad, Zamira-V Díaz Riascos, Judit Tomsen-Melero, Elisabet González‐Mira, Josefina Casas, Edgar Cristóbal‐Lecina, Albert Font, José Luís Corchero, Daniel Pulido, Andreu Soldevila, Míriam Royo, Alba Córdoba, Josep Merlo‐Mas, Lidia Ferrer, Santi Sala, Sandra Mancilla-Zamora, Monserrat Llaguno‐Munive, Paula Zamora-Pérez, Belén García-Prats, Nora Ventosa, Ibane Abasolo   +20 more
semanticscholar   +3 more sources

Identification of lysosomal and extralysosomal globotriaosylceramide (GB3) accumulations in the endomyocardial biopsies before the occurrence of typical pathological changes of the patients with Fabry disease

Molecular Genetics and Metabolism, 2018
Dau‐Ming Niu, Ming-Jia Hsu, Fu‐Pang Chang, Yung-Hsiu Lu, Sheng‐Che Hung, Yu-Chen Wang, Jen‐Fan Hang, An‐Hang Yang, Han-Rei Lee, Shih‐Hsien Sung, Yen-Feng Wang, Wen‐Chung Yu, Ting‐Rong Hsu, Po‐Hsun Huang, Sheng-Kai Chang, Ivan Dzhagalov, Chia‐Lin Hsu   +16 more
semanticscholar   +3 more sources

A practical and enantioselective synthesis of glycosphingolipids and related compounds. Total synthesis of globotriaosylceramide (Gb3)

Journal of the American Chemical Society, 1988
K. C. Nicolaou, Thomas J. Caulfield, Hiromi Kataoka, T. KUMAZAWA   +3 more
semanticscholar   +3 more sources

Falsely elevated urinary Gb3 (globotriaosylceramide, CTH, GL3)

Molecular Genetics and Metabolism, 2009
and C17-Gb3 as internal standards. Ten microliters are injected into a UPLC-MS/MS for the simultaneous determination of creatinine and Gb3. Urine of 100 healthy subjects from newborns to 65 years old was analyzed. The concentration of creatinine in urine varied widely due to diet or age: from less then 1 lmol/mL in infants and some adults to higher ...
Sabrina Forni, Xiaowei Fu, Raphael Schiffmann, Lawrence Sweetman   +3 more
openalex   +3 more sources

Synthesis of a Deuterium-Labeled Globotriaosylceramide Probe for Potential Imaging of Subcellular Localization of Gb3 Using NanoSIMS

Russian Journal of Organic Chemistry, 2021
Mohamed R. E. Aly, Islam H. El Azab
semanticscholar   +3 more sources