Results 41 to 50 of about 5,162 (179)
Expression of Globotriaosylceramide in Human CD4+ T-cells [PDF]
, 2011 Globotriaosylceramide (Gb3) is a resistance factor against human immunodeficiency virus (HIV) infection, but its expression has not been studied on human CD4+ T-cells. It was proposed that CD4+ T-cells may express Gb3 upon in vitro stimulation.
Kim, Minji
core +2 more sources
Acroparesthesia in a Female: Diagnostic Dilemma
Case Reports in Medicine, 2014 Fabry disease is an X-linked lysosomal storage disorder caused by deficient activity of a-galactosidase A (also known as ceramide trihexosidase) and resultant accumulation of globotriaosylceramide (Gb3) and related glycophospholipids.
Fnu Kelash +2 more
doaj +1 more source
A CRISPR Screen Identifies LAPTM4A and TM9SF Proteins as Glycolipid-Regulating Factors
iScience, 2019 Summary: Glycosphingolipids (GSLs) are produced by various GSL-synthesizing enzymes, but post-translational regulation of these enzymes is incompletely understood.
Toshiyuki Yamaji +6 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2020 Shiga toxin (Stx) produced by enterohemorrhagic E. coli produces hemolytic uremic syndrome and encephalopathies in patients, which can lead to either reversible or permanent neurological abnormalities, or even fatal cases depending on the degree of ...
Clara Berdasco +3 more
doaj +1 more source
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype
EMBO Molecular Medicine, 2021 Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN3 and CLN7 ...
Chiara Soldati +22 more
doaj +1 more source
Journal of Lipid Research, 2011 The aim of our study was to measure globotriaosylceramide (Gb3) and lyso-Gb3 levels by tandem mass spectrometry in the urine and kidney in Fabry (gla knockout) mice and wild-type controls.
Brandon Durant +7 more
doaj +1 more source
Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy
The Journal of Clinical Investigation, 2023 Current therapies for Fabry disease are based on reversing intracellular accumulation of globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated stabilization of the defective enzyme, thereby alleviating lysosomal ...
Fabian Braun +37 more
doaj +1 more source
Shiga toxin binding to glycolipids and glycans. [PDF]
PLoS ONE, 2012 Immunologically distinct forms of Shiga toxin (Stx1 and Stx2) display different potencies and disease outcomes, likely due to differences in host cell binding.
Karen M Gallegos +5 more
doaj +1 more source
Search of molecules associating with Gb3 in glycosphingolipid-enriched microdomain [PDF]
, 2004 Silurus asotus (catfish) egg lectin (SAL) is a member of rhamnose-binding lectin family, and binds to globotriaosylceramide (Gb3) localized in a glycosphingolipid-enriched microdomain (GEM) on several tumor cell lines. It is known that GEM is involved in
細野, 雅祐 +14 more
core +1 more source
Globotriaosylceramide (Gb3) expression and membrane presentation: implications for the hemolytic uremic syndrome and human immunodeficiency virus infection [PDF]
, 2003 The binding of verotoxin 1 (VT1), verotoxin 2 (VT2) and monoclonal anti-Gb 3 (38.13) to a series of globotriaosylceramide (Gb3) analogues and to structures within the human kidney were compared.
Chark, Davin
core +1 more source