Results 1 to 10 of about 31,505 (190)

Structural Diversities of Lectins Binding to the Glycosphingolipid Gb3 [PDF]

Frontiers in Molecular Biosciences, 2021
Glycolipids are present on the surfaces of all living cells and thereby represent targets for many protein receptors, such as lectins. Understanding the interactions between lectins and glycolipids is essential for investigating the functions of lectins ...
Lina Siukstaite, Lina Siukstaite, Anne Imberty, Winfried Römer, Winfried Römer, Winfried Römer   +5 more
doaj   +5 more sources

RIPK3 Contributes to Lyso-Gb3-Induced Podocyte Death [PDF]

Cells, 2021
Fabry disease is a lysosomal storage disease with an X-linked heritage caused by absent or decreased activity of lysosomal enzymes named alpha-galactosidase A (α-gal A).
So-Young Kim, Samel Park, Seong-Woo Lee, Ji-Hye Lee, Eun Soo Lee, Miri Kim, Youngjo Kim, Jeong Suk Kang, Choon Hee Chung, Jong-Seok Moon, Eun Young Lee   +10 more
doaj   +4 more sources

Determination of Gb3 and Lyso-Gb3 in Fabry Disease-Affected Patients by LC-MRM/MS

Separations
Limited or absent activity of the enzyme α-galactosidase A (α-Gal A), due to mutation in the related gene on the X chromosome, leads to the development of a rare hereditary and genetic disease known as Fabry disease (FD).
Gennaro Battaglia, Gabriella Pinto, Carolina Fontanarosa, Michele Spinelli, Anna Illiano, Stefania Serpico, Lorenzo Chiariotti, Roberta Risoluti, Stefano Materazzi, Angela Amoresano   +9 more
doaj   +4 more sources

Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research

Cellular & Molecular Biology Letters
Human Gb3/CD77 synthase (α1,4-galactosyltransferase, P1/Pk synthase, UDP-galactose: β-d-galactosyl-β1-R 4-α-d-galactosyltransferase, EC 2.4.1.228) forms Galα1 → 4Gal structures on glycosphingolipids and glycoproteins.
Katarzyna Szymczak-Kulus, Marcin Czerwinski, Radoslaw Kaczmarek   +2 more
doaj   +2 more sources

The interaction between flagellin and the glycosphingolipid Gb3 on host cells contributes to Bacillus cereus acute infection

Virulence, 2020
Bacillus cereus is an opportunistic pathogen that can cause emetic or diarrheal foodborne illness. Previous studies have identified multiple pathogenic B. cereus strains and characterized a variety of virulence factors.
Song Gao, Chengpei Ni, Wenhua Huang, Huaijie Hao, Hua Jiang, Qingyu Lv, Yuling Zheng, Peng Liu, Decong Kong, Yongqiang Jiang   +9 more
doaj   +2 more sources

A Shiga Toxin B-Subunit-Based Lectibody Boosts T Cell Cytotoxicity towards Gb3-Positive Cancer Cells

Cells, 2023
Aberrant glycosylation plays a crucial role in tumour progression and invasiveness. Tumour-associated carbohydrate antigens (TACAs) represent a valuable set of targets for immunotherapeutic approaches.
Jana Tomisch, Vincent Busse, Francesca Rosato, Olga N. Makshakova, Pavel Salavei, Anna-Sophia Kittel, Emilie Gillon, Levin Lataster, Anne Imberty, Ana Valeria Meléndez, Winfried Römer   +10 more
doaj   +2 more sources

Enzymatic synthesis of Gb3 and iGb3 ceramides [PDF]

Carbohydrate Research, 2010
Gb3 and iGb3 are physiologically important trihexosylceramides with a terminal alpha-d-Galp-(1-->4)-beta-d-Galp- and alpha-d-Galp-(1-->3)-beta-d-Galp sequence, respectively. In particular iGb3 is attracting considerable attention as it is believed to serve as a ligand for natural killer T cells. Whether or not iGb3 is present in humans and which enzyme
Norman Dovichi, Joel Weadge, Bent O Petersen   +2 more
exaly   +3 more sources

Differential recognition of lipid domains by two Gb3-binding lectins [PDF]

Scientific Reports, 2020
The two lectins LecA from Pseudomonas aeruginosa and the B-subunit of Shiga toxin from Shigella dysenteriae (StxB) share the glycosphingolipid globotriaosylceramide (Gb3) as receptor.
Thomas Schubert, T. Sych, J. Madl, Maokai Xu, Ramin Omidvar, Lukas J. Patalag, Annika Ries, K. Kettelhoit, Annette Brandel, Y. Mély, C. Steinem, D. Werz, Roland Thuenauer, W. Römer   +13 more
semanticscholar   +7 more sources

Nanomedicines for DNA and interference RNA co-delivery: Combined gene therapy for Fabry disease [PDF]

International Journal of Pharmaceutics: X
Fabry disease (FD) is a multisystemic rare disorder caused by mutations in the GLA gene encoding α-Galactosidase A (α-Gal A) enzyme. The deficiency of this enzyme leads to progressive lysosomal accumulation of glycosphingolipids, especially ...
Marina Beraza-Millor, Paula Fernández-Muro, Madalen Arribas-Galarreta, Ana del Pozo-Rodríguez, Alicia Rodríguez-Gascón, María Ángeles Solinís   +5 more
doaj   +2 more sources

The use and performance of lyso-Gb3 for the diagnosis and monitoring of Fabry disease: A systematic literature review

Molecular Genetics and Metabolism
BACKGROUND Fabry disease (FD) is a rare, X-linked lysosomal storage disorder in which a lack of alpha-galactosidase (α-Gal A) enzyme activity leads to intracellular accumulation of deacylated globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-
Karen Tylee, Albina Nowak, Uma Rámaswámí   +2 more
exaly   +2 more sources