Results 11 to 20 of about 31,524 (206)
BMB Reports, 2009 Globotriaosylceramide (Gb3) and globotetraosylceramide (Gb4) are the proposed functional receptors for Shiga toxin (Stx). To elucidate the effect of Gb3 content on Stx-induced cytotoxicity in HeLa cells, we cloned HeLa cells and determined the correlation between glycolipids content and Stx-induced cytotoxicity. The 29 HeLa cell clone (HLCC) lines used
Satoshi Ishii
exaly +4 more sources
Toxins, 2010 A major problem with anti-cancer drug treatment is the development of acquired multidrug resistance (MDR) of the tumor cells. Verotoxin-1 (VT-1) exerts its cytotoxicity by targeting the globotriaosylceramide membrane receptor (Gb3), a glycolipid ...
Kjell Grankvist, Johansson Anders
exaly +3 more sources
Synthesis of an Aminooxy Derivative of the Trisaccharide Globotriose Gb3 [PDF]
Journal of Carbohydrate Chemistry, 2014 The synthesis of α-aminooxy trisaccharide moiety [α-d-Gal-(1,4)-β-d-Gal-(1,4)-β-d-Glc-α-aminooxy], related to the cell surface globotriaosylceramide (Gb3) receptor of the B subunit of the AB5 Shiga toxin of Shigella dysenteriae, has been synthesized for the first time in 11 steps with a 15% overall isolated yield.
Peter Andreana, Samir Ghosh
exaly +3 more sources
Advanced ScienceCutaneous fibroblast heterogeneity is mechanistically linked to wound repair outcomes and fibrotic progression, with glycosphingolipid metabolism emerging as a critical determinant of physiological fibroblast diversity.
Sujie Xie +13 more
doaj +2 more sources
Fabry Disease Nephropathy: Compendium of “in vitro” and “in vivo” Renal Effects of Globotriaosylsphingosine [PDF]
Kidney & Blood Pressure ResearchBackground: Renal damage in Fabry disease (FD) is a consequence of pathological and progressive glycosphingolipids accumulation, which occurs in different magnitudes among FD phenotypes, but is a constant renal tissue phenomenon in all ...
Sebastián Pedro Antonio Jaurretche +5 more
doaj +2 more sources
Lyso-Gb3 modulates the gut microbiota and decreases butyrate production [PDF]
Scientific Reports, 2019 Fabry disease is a rare X-linked lysosomal storage disorder resulting from deficient activity of α-galactosidase A, leading to the accumulation of glycosphingolipids such as globotriaosylsphingosine (lyso-Gb3).
J. Aguilera-Correa +7 more
semanticscholar +5 more sources
Pharmaceutics, 2018 Fabry disease is a rare lysosomal storage disorder resulting from the lack of α-Gal A gene activity. Globotriaosylceramide (GB3, ceramide trihexoside) is a novel endogenous biomarker which predicts the incidence of Fabry disease. At the early stage
Mi Hye Kim, Byeongill Lee, Young Shin
exaly +3 more sources
Transmembrane BAX Inhibitor Motif Containing (TMBIM) Family Proteins Perturbs a trans-Golgi Network Enzyme, Gb3 Synthase, and Reduces Gb3 Biosynthesis [PDF]
Journal of Biological Chemistry, 2010 Globotriaosylceramide (Gb3) is a well known receptor for Shiga toxin (Stx), produced by enterohemorrhagic Escherichia coli and Shigella dysenteriae. The expression of Gb3 also affects several diseases, including cancer metastasis and Fabry disease, which prompted us to look for factors involved in its metabolism.
Kiyotaka Nishikawa +2 more
exaly +3 more sources
The Gb3-synthase A4GALT is an epigenetically regulated driver of tumor invasiveness in gastrointestinal cancer [PDF]
BMC CancerBackground Tumor lipid metabolism has emerged as a critical, yet underexplored, determinant of cancer progression with clinical and prognostic importance.
Noah-David Hirsch +11 more
doaj +2 more sources
Anti-Gb3 monoclonal antibody inhibits angiogenesis and tumor development.
PLoS ONE, 2012 Inhibiting the growth of tumor vasculature represents one of the relevant strategies against tumor progression. Between all the different pro-angiogenic molecular targets, plasma membrane glycosphingolipids have been under-investigated.
Ariane Desselle +9 more
doaj +5 more sources