Results 41 to 50 of about 31,524 (206)
Shiga toxin binding to glycolipids and glycans. [PDF]
PLoS ONE, 2012 Immunologically distinct forms of Shiga toxin (Stx1 and Stx2) display different potencies and disease outcomes, likely due to differences in host cell binding.
Karen M Gallegos +5 more
doaj +1 more source
Molecular Genetics and Metabolism Reports, 2021 Drug-induced lysosomal storage disease (DILSD) caused by cationic amphiphilic drugs (CADs), which exhibits toxic manifestations and pathological findings mimicking Fabry disease (α-galactosidase A deficiency), has attracted the interests of clinicians ...
Takahiro Tsukimura +5 more
doaj +1 more source
Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3. [PDF]
PLoS ONE, 2008 Human tumors differ from normal tissues in their capacity to present Hsp70, the major stress-inducible member of the HSP70 family, on their plasma membrane.
Mathias Gehrmann +7 more
doaj +1 more source
Skin Globotriaosylceramide 3 Load Is Increased in Men with Advanced Fabry Disease. [PDF]
PLoS ONE, 2016 The X-chromosomally linked life-limiting Fabry disease (FD) is associated with deposits of the sphingolipid globotriaosylceramide 3 (Gb3) in various tissues. Skin is easily accessible and may be used as an additional diagnostic and follow-up medium.
Nurcan Üçeyler +6 more
doaj +1 more source
Journal of Biological Chemistry, 2021 The human Gb3/CD77 synthase, encoded by the A4GALT gene, is an unusually promiscuous glycosyltransferase. It synthesizes the Galα1→4Gal linkage on two different glycosphingolipids (GSLs), producing globotriaosylceramide (Gb3, CD77, Pk) and the P1 antigen.
Katarzyna Szymczak-Kulus +15 more
semanticscholar +1 more source
Molecular Genetics and Metabolism Reports, 2021 In Fabry disease, accumulation of glycolipids, predominantly globotriaosylceramide (Gb3), affects the kidneys, and nephropathy is one of the important disorders that influence the disease severity and prognosis of patients.
Tomoko Shiga +4 more
doaj +1 more source
Regulation of Gb3 Expression on Dendritic Cells [PDF]
Journal of Life Science, 2007 Infection with Shiga-like toxin (SLT)-producing Escherichia coli causes a spectrum of illnesses with high morbidity and mortality. Host mediators play an important role in the pathogenesis of SLT-I toxicity. We here investigated the effect of SLT-I on tumor necrosis factor-α (TNF-α) production, effect of TNF-α on glycolipid globotriaosyleramide (Gb3 ...
Suk-Hwan Lim +6 more
openaire +1 more source
Missing the sweet spot: one of the two N-glycans on human Gb3/CD77 synthase is expendable
bioRxiv, 2021 N-glycosylation is a ubiquitous posttranslational modification that may influence folding, subcellular localization, secretion, solubility and oligomerization of proteins.
Krzysztof Mikołajczyk +13 more
semanticscholar +1 more source
Two Distinct Gb3/CD77 Signaling Pathways Leading to Apoptosis Are Triggered by Anti-Gb3/CD77 mAb and Verotoxin-1 [PDF]
Journal of Biological Chemistry, 2003 Globotriasosylceramide (Gb3), a neutral glycosphingolipid, is the B-cell differentiation antigen CD77 and acts as the receptor for most Shiga toxins, including verotoxin-1 (VT-1). We have shown that both anti-Gb3/CD77 mAb and VT-1 induce apoptosis in Burkitt's lymphoma cells.
Tétaud, Cécile +10 more
openaire +2 more sources
Cellular and Molecular Life Sciences, 2021 The opportunistic pathogen Pseudomonas aeruginosa has gained precedence over the years due to its ability to develop resistance to existing antibiotics, thereby necessitating alternative strategies to understand and combat the bacterium.
Annette Brandel +12 more
semanticscholar +1 more source