Results 61 to 70 of about 31,524 (206)
Verotoxin Receptor-Based Pathology and Therapies
Frontiers in Cellular and Infection Microbiology, 2020 Verotoxin, VT (aka Shiga toxin,Stx) is produced by enterohemorrhagic E. coli (EHEC) and is the key pathogenic factor in EHEC-induced hemolytic uremic syndrome (eHUS-hemolytic anemia/thrombocytopenia/glomerular infarct) which can follow gastrointestinal ...
Clifford Lingwood
doaj +1 more source
Distribution of Gb3 Immunoreactivity in the Mouse Central Nervous System
Toxins, 2010 We have shown previously that neurons in the mouse spinal cord express Gb3. We show in this article that distribution of anti-Gb3-Ab reactivity occurs in many different types of neurons of different areas of the central nervous system (CNS).
Tom Obrig, Fumiko Obata
doaj +1 more source
Gb3 trisaccharide-bearing exosomes as a novel neutralizer for Shiga toxin type 1
bioRxivShiga toxin types 1 (Stx1) and 2 (Stx2), produced by Shiga toxin-producing Escherichia coli (STEC) and Shigella dysenteriae, are key virulence factors responsible for severe foodborne diseases, such as hemorrhagic colitis and hemolytic uremic syndrome ...
Krzysztof Mikołajczyk
semanticscholar +1 more source
FASEB bioAdvances, 2020 Glucosylceramide synthase (GCS) is a key enzyme catalyzing ceramide glycosylation to generate glucosylceramide (GlcCer), which in turn serves as the precursor for cells to produce glycosphingolipids (GSLs).
K. Roy +8 more
semanticscholar +1 more source
PLoS ONE, 2012 BackgroundFabry disease (FD) is caused by a deficiency of the lysosomal enzyme alpha-galactosidase A (GLA) resulting in the accumulation of globotriaosylsphingosine (Gb3) in a variety of tissues.
Mehdi Namdar +8 more
doaj +1 more source
bioRxiv, 2020 The opportunistic pathogen Pseudomonas aeruginosa is responsible for a high number of acute and chronic hospital-acquired infections. As it develops more and more resistances against existing antibiotics, P.
Annette Brandel +11 more
semanticscholar +1 more source
Identification and characterization of the human Gb3/CD77 synthase gene promoter [PDF]
Glycobiology, 2008 Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain. Several studies have demonstrated that VT induces endothelial cell (EC) death via the VT receptor globotriaosylceramide (Gb3/CD77) leading to this symptom. Inflammatory mediators which are produced as a result of E. coli O157 infection, increase
Tetsuya, Okuda, Ken-Ichi, Nakayama
openaire +2 more sources
A CRISPR Screen Identifies LAPTM4A and TM9SF Proteins as Glycolipid-Regulating Factors
iScience, 2019 Summary: Glycosphingolipids (GSLs) are produced by various GSL-synthesizing enzymes, but post-translational regulation of these enzymes is incompletely understood.
Toshiyuki Yamaji +6 more
doaj +1 more source
Modeling Downside Risks for China's Security Markets: Does Greenness Make Bonds a Safer Haven?
Scottish Journal of Political Economy, EarlyView.ABSTRACT Motivated by its current defective governance regime and institutional characteristics of green finance, this study models Value‐at‐Risk and Expected Shortfall of security markets for China. We extend Patton et al.'s (2019) models by introducing four exogenous risk factors including China's climate policy uncertainty (CCPU).
Xiao‐Ming Li
wiley +1 more source
Cellular Lyso-Gb3 Is a Biomarker for Mucolipidosis II
International Journal of Molecular SciencesLysosomal storage diseases are caused by defective lysosomal function, such as impaired lysosomal enzyme activities, which include more than 70 different diseases. Although biomarkers and therapies have been developed to date for some of them, many others remain challenging to diagnose and treat.
Seigo Terawaki +4 more
openaire +2 more sources