Results 81 to 90 of about 31,524 (206)

Selective foraging by aardvarks Orycteropus afer on termite mounds: influence of mound structure, spatial distribution, and geology in a savanna landscape

Wildlife Biology, Volume 2026, Issue 4, July 2026.
Predator foraging patterns reflect how animals interact with spatially heterogeneous resources, yet how these patterns manifest across complex landscapes remains poorly understood. We investigated selective excavation of termite mounds by aardvarks Orycteropus afer in Gonarezhou National Park, examining how mound structural characteristics, size ...
Justice Muvengwi, Neo Debeila
wiley   +1 more source

Fabry cardiomyopathy: Gb3‐induced auto‐reactive panmyocarditis requiring heart transplantation

ESC Heart Failure, 2020
Resistance to enzyme replacement therapy (ERT) is a major therapeutic challenge in Fabry disease (FD). Recent reports attribute to immune‐mediated inflammation a main role in promoting disease progression and resistance to ERT.
A. Frustaci, M. Scarpa, Rosalia Maria da Riol, C. Agrati, N. Finato, R. Verardo, C. Grande, C. Chimenti, C. Nora, M. Russo, U. Livi   +10 more
semanticscholar   +1 more source

An Unusual Etiology of Bayés' Syndrome: Fabry Disease

Annals of Noninvasive Electrocardiology, Volume 31, Issue 4, July 2026.
This patient with gene confirmed Fabry disease had advanced interatrial conduction block as seen on atrial‐specific vector tracing demonstrating sinus bradycardia with first‐degree AV block and sinus P‐wave terminal delay with biphasic morphology. The patient was later diagnosed with atrial fibrillation, which led to the diagnosis of Bayés' syndrome ...
Nicholas E. Kunce, Andre Silva, Mark Haigney, Adam Kisling   +3 more
wiley   +1 more source

Common Hematologic Emergencies—Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias—A Pivotal Role of Clinical Laboratory

International Journal of Laboratory Hematology, Volume 48, Issue 3, Page 521-530, June 2026.
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova, Nicolas Ulrich Edgar, Anton V. Rets   +2 more
wiley   +1 more source

Massive accumulation of globotriaosylceramide in various tissues from a Fabry patient with a high antibody titer against alpha-galactosidase A after 6 years of enzyme replacement therapy

Molecular Genetics and Metabolism Reports, 2020
Fabry disease is an X-linked metabolic disorder due to a pathogenic mutation of the GLA gene. The accumulation of globotriaosylceramide (Gb3) damages multiple organs, including the heart, kidney and nervous system, especially in classical type Fabry ...
Kenichi Hongo, Toru Harada, Eiko Fukuro, Masahisa Kobayashi, Toya Ohashi, Yoshikatsu Eto   +5 more
doaj   +1 more source

Septins in the Middle—Makers and Breakers of Membrane Contact Sites

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
Septins are a family of GTP‐binding proteins that assemble into heteromeric oligomers and polymers, associating with specific membrane domains and organelles according to their subunit composition. Growing evidence places septins at membrane contact sites (MCS) — key hubs for intracellular communication that mediate exchange of ions, lipids, and ...
TrishaJean J. Holt, Elias T. Spiliotis
wiley   +1 more source

Chemically synthesized Gb3 glycosphingolipids: tools to access their function in lipid membranes

European Biophysics Journal, 2020
Gb3 glycosphingolipids are the specific receptors for bacterial Shiga toxin. Whereas the trisaccharidic head group of Gb3 defines the specificity of Shiga toxin binding, the lipophilic part composed of sphingosine and different fatty acids is suggested ...
Jeremias Sibold, Somayeh Ahadi, D. Werz, C. Steinem   +3 more
semanticscholar   +1 more source

Globotriaosylceramide, Gb3, is an alternative functional receptor for Shiga-like toxin 2e [PDF]

Infection and Immunity, 1995
We reexamined the binding specificity of the Shiga-like toxin variant associated with porcine edema disease, SLT2e, which is reported to be more cytotoxic for Vero cells than for HeLa cells, by using receptor-deficient cells and a liposomal insertion system for purified glycolipids.
G T, Keusch, M, Jacewicz, D W, Acheson, A, Donohue-Rolfe, A V, Kane, R H, McCluer   +5 more
openaire   +2 more sources

Development of CAR NK Cell Lines Selectively Targeting Cancer Cells Expressing Membrane Hsp70

MedComm, Volume 7, Issue 5, May 2026.
This work presents a novel CAR NK cell platform targeting membrane‐bound Hsp70, a tumor‐specific antigen broadly expressed on solid tumors but not on normal cells. Computational modeling confirmed strong binding between the CAR construct and the Hsp70‐derived TKD peptide.
Khouloud Hachani, Mina Yazdi, Charlotte Carcopino, Fatemeh Khademi Moghadam, Micholas Dean Smith, Anskar Trill, Marcel P. Trefny, Morteza Hasanzadeh Kafshgari, Cosima C. Hoch, Abdallah Gaballa, Bayan Alkotub, Jennifer Altomonte, A. Graham Pockley, Ernst Wagner, Barbara Wollenberg, Sebastian Kobold, Gabriele Multhoff, Ali Bashiri Dezfouli   +17 more
wiley   +1 more source

Incidental finding of cornea verticillata or lamellar inclusions in kidney biopsy: measurement of lyso-Gb3 in plasma defines between Fabry disease and drug-induced phospholipidosis.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2020
INTRODUCTION Therapy with cationic amphiphilic drugs (Amiodarone or hydroxychloroquine) may result in biochemically and ultrastructurally similar lipid inclusions in many cells also affected by Fabry disease (FD). In addition, it often results in similar
J. Politei, J. Frabasil, C. Durand, S. Di Pietrantonio, A. Fernández, V. Alberton, D. Velasques Rivas, R. Barriales-Villa, J. Larrañaga-Moreira, A. Schenone   +9 more
semanticscholar   +1 more source