Results 1 to 10 of about 26,122 (235)

Revealing the roles of glycosphingolipid metabolism pathway in the development of keloid: a conjoint analysis of single-cell and machine learning

Frontiers in Immunology, 2023
Keloid is a pathological scar formed by abnormal wound healing, characterized by the persistence of local inflammation and excessive collagen deposition, where the intensity of inflammation is positively correlated with the size of the scar formation ...
Binyu Song, Yu Zheng, Hao Chi, Yuhan Zhu, Zhiwei Cui, Lin Chen, Guo Chen, Botao Gao, Yichen Du, Zhou Yu, Baoqiang Song   +10 more
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GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth

Journal of Lipid Research, 2022
Golgi membrane protein 1 (GOLM1) is a Golgi-resident type 2 transmembrane protein known to be overexpressed in several cancers, including hepatocellular carcinoma (HCC), as well as in viral infections.
Meghana Nagaraj, Marcus Höring, Maria A. Ahonen, Van Dien Nguyen, You Zhou, Helena Vihinen, Eija Jokitalo, Gerhard Liebisch, P.A. Nidhina Haridas, Vesa M. Olkkonen   +9 more
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The Involvement of Lactosylceramide in Central Nervous System Inflammation Related to Neurodegenerative Disease

Frontiers in Aging Neuroscience, 2021
Neurodegenerative diseases are a class of slow-progressing terminal illnesses characterized by neuronal lesions, such as multiple sclerosis [MS, Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS)]. Their incidence
Wen Yu, Wen Yu, Jun Ying, Jun Ying, Xifeng Wang, Xing Liu, Xing Liu, Tiancheng Zhao, Sungtae Yoon, Qingcui Zheng, Qingcui Zheng, Yang Fang, Yang Fang, Danying Yang, Danying Yang, Fuzhou Hua, Fuzhou Hua   +16 more
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Structure Elucidation of Calyxoside B, a Bipolar Sphingolipid from a Marine Sponge Cladocroce sp. through the Use of Beckmann Rearrangement

Marine Drugs, 2021
Marine sponges are an excellent source of biologically active secondary metabolites. We focus on deep-sea sponges for our discovery study. A marine sponge Cladocroce sp. exhibited cytotoxic activity in the bioactivity screening.
Kenji Sugawara, Hiroshi Watarai, Yuji Ise, Hisayoshi Yokose, Yasuhiro Morii, Nobuhiro Yamawaki, Shigeru Okada, Shigeki Matsunaga   +7 more
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The Cellular and Chemical Biology of Endocytic Trafficking and Intracellular Delivery—The GL–Lect Hypothesis

Molecules, 2021
Lipid membranes are common to all forms of life. While being stable barriers that delimitate the cell as the fundamental organismal unit, biological membranes are highly dynamic by allowing for lateral diffusion, transbilayer passage via selective ...
Ludger Johannes
doaj   +1 more source

Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease

Frontiers in Neurology, 2021
Parkinson's disease (PD) is a movement disorder attributed to the loss of dopaminergic (DA) neurons mainly in the substantia nigra pars compacta. Motor symptoms include resting tremor, rigidity, and bradykinesias, while non-motor symptoms include ...
Albert Frank Magnusen, Shelby Loraine Hatton, Reena Rani, Manoj Kumar Pandey, Manoj Kumar Pandey   +4 more
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Glycosphingolipids and Infection. Potential New Therapeutic Avenues

Frontiers in Cell and Developmental Biology, 2019
Glycosphingolipids (GSLs), the main topic of this review, are a subclass of sphingolipids. With their glycans exposed to the extracellular space, glycosphingolipids are ubiquitous components of the plasma membrane of cells.
Johannes M. F. G. Aerts, M. Artola, M. van Eijk, M. J. Ferraz, R. G. Boot   +4 more
doaj   +1 more source

Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

Pharmaceutics, 2023
Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand–receptor pair based on a dimeric, engineered derivative of the Pseudomonas aeruginosa lectin LecA, here ...
Maokai Xu, Maria Antonova, Pavel Salavei, Katharina Illek, Ana Valeria Meléndez, Ramin Omidvar, Roland Thuenauer, Olga Makshakova, Winfried Römer   +8 more
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Synthesis, Inhibitory Effects on Nitric Oxide and Structure-Activity Relationships of a Glycosphingolipid from the Marine Sponge Aplysinella rhax and Its Analogues

Molecules, 2011
The novel glycosphingolipid, b-D-GalNAcp(1®4)[a-D-Fucp(1®3)]-b-D-GlcNAcp(1®)Cer (A), isolated from the marine sponge Aplysinella rhax has a unique structure, with D-fucose and N-acetyl-D-galactosamine moieties attached to a reducing-end N-acetyl-D ...
Naohiro Ohshima, Ai Hasegawa, Frank Schweizer, Tadahiro Takeda, Fumiyuki Kiuchi, Noriyasu Hada, Yuzo Fujita   +6 more
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Isolation and Structure Elucidation of GM4-Type Gangliosides from the Okinawan Starfish Protoreaster nodosus

Marine Drugs, 2012
Three new ganglioside molecular species, termed PNG-1, PNG-2A, and PNG-2B were isolated from pyloric caeca of the starfish Protoreaster nodosus. Their structures were elucidated using a combination of spectroscopic and chemical methods, and characterized
Tomofumi Miyamoto, Ryuichi Higuchi, Masanori Inagaki, Chiaki Tanaka, Ke Pan   +4 more
doaj   +1 more source