Results 21 to 30 of about 26,122 (235)
Sequential One-Pot Multienzyme Chemoenzymatic Synthesis of Glycosphingolipid Glycans [PDF]
, 2016 Glycosphingolipids are a diverse family of biologically important glycolipids. In addition to variations on the lipid component, more than 300 glycosphingolipid glycans have been characterized.
Chen, Xi +26 more
core +1 more source
Biomolecules, 2020 Due to the limited intrinsic healing potential of cartilage, injury to this tissue may lead to osteoarthritis. Human induced pluripotent stem cells (iPSCs), which can be differentiated into chondrocytes, are a promising source of cells for cartilage ...
Liang Xu +9 more
doaj +1 more source
Machine learning identifies glycosphingolipid signature linking immune dysregulation and clinical prognosis in uveal melanoma. [PDF]
Discov OncolPurpose To investigate glycosphingolipid biosynthesis (GSB) dysregulation in uveal melanoma (UVM) and develop a machine learning-driven prognostic signature bridging GSB activity, tumor microenvironment, and clinical outcomes.
Guo H, Li B, Zhang Z, Chen J.
europepmc +2 more sources
Glucosylceramide modulates membrane traffic along the endocytic pathway
Journal of Lipid Research, 2002 Glycosphingolipids are endocytosed and targeted to the Golgi apparatus, but are mistargeted to lysosomes in numerous sphingolipidoses. Substrate reduction therapy utilizes imino sugars to inhibit glucosylceramide synthase and potentially abrogate the ...
Dan J. Sillence +6 more
doaj +1 more source
The fate and function of glycosphingolipid glucosylceramide [PDF]
, 2003 In higher eukaryotes, glucosylceramide is the simplest member and precursor of a fascinating class of membrane lipids, the glycosphingolipids.
Degroote, S. +6 more
core +1 more source
Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells
Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells represent a unique population of CD1d-restricted T lymphocytes expressing an invariant T cell receptor encoded by Vα14-Jα18 and Vα24-Jα18 gene segments in mice and humans, respectively.
Zoran V. Popovic +7 more
doaj +1 more source
Neurobiology of Disease, 2021 Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD).
Mali Cosden +18 more
doaj +1 more source
The application of glycosphingolipid arrays to autoantibody detection in neuroimmunological disorders [PDF]
, 2014 Serum autoantibodies directed towards a wide range of single glycosphingolipids, especially gangliosides, in humans with autoimmune peripheral neuropathies have been extensively investigated since the 1980s and these are widely measured both in clinical ...
Galban Horcajo, Francesc
core +7 more sources
, 1997 Specific glycosphingolipid antigens of Leishmania (L.) amazonensis amastigotes reactive with the monoclonal antibodies (MoAbs) ST-3, ST-4 and ST-5 were isolated, and their structure was partially elucidated by negative ion fast atom bombardment mass ...
A.H. Straus +9 more
core +2 more sources
Multiple Roles of Glycans in Hematological Malignancies
Frontiers in Oncology, 2018 The three types of blood cells (red blood cells for carrying oxygen, white blood cells for immune protection, and platelets for wound clotting) arise from hematopoietic stem/progenitor cells in the adult bone marrow, and function in physiological ...
Xingchen Pang +5 more
doaj +1 more source