Results 1 to 10 of about 17,651 (213)

The role of α2,3-linked sialylation on clear cell type epithelial ovarian cancer

Taiwanese Journal of Obstetrics and Gynecology, 2018
Objective: Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous type epithelial ovarian cancer (EOC).
Chia-Ming Chang, Kuo-Chang Wen
exaly   +4 more sources

IgG sialylation occurs in B cells pre antibody secretion [PDF]

Frontiers in Immunology
Sialic acids as terminal sugar residues on cell surface or secreted proteins have many functional roles. In particular, the presence or absence of α2,6-linked sialic acid residues at the immunoglobulin G (IgG) Fc fragment can switch IgG effector ...
Maja Hanic, Lars Nitschke, Anja Lux
exaly   +4 more sources

Enhanced sialylation of bone marrow mesenchymal stromal cells contributes to immune remodeling through macrophage polarization in multiple myeloma patients [PDF]

Frontiers in Immunology
IntroductionIn multiple myeloma (MM), the immune system is disrupted, partly due to tumor-modified bone marrow mesenchymal stromal cells (BM-MSCs). These MSCs show altered glycosylation, including increased sialylation, which may promote immune evasion ...
Achille Ruer, David Van Morckhoven, Karlien Pieters, Nathalie Meuleman, Nathalie Meuleman, Laurence Lagneaux, Basile Stamatopoulos   +6 more
doaj   +2 more sources

Sialylation is involved in cell fate decision during development, reprogramming and cancer progression

Protein and Cell, 2018
Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a biologically important modification that is involved in embryonic development, neurodevelopment, reprogramming, oncogenesis and immune responses.
Junjun Ding
exaly   +3 more sources

Tumor sialylation regulates G-CSF stability and promotes neutrophil-mediated immunosuppression in breast cancer [PDF]

Nature Communications
Breast cancer is the most prevalent cancer among women, yet immune checkpoint inhibitors remain largely ineffective in the majority of patients. Here we show that tumor sialylation is negatively associated with T cell infiltration across molecular breast
Stefan Mereiter, Gustav Jonsson, Tiago Oliveira, Ingrid-Judith Garberis, Johannes Helm, Markus Abeln, Ann-Kristin Jochum, Wolfram Jochum, Max J. Kellner, Marek Feith, Vanessa Tkalec, Karolina Wasilewska, Jie Jiao, David Hoffmann, Lukas Emsenhuber, Felix Holstein, Anna C. Obenauf, Guido Kroemer, Magali Lacroix-Triki, Omar Hasan Ali, Lukas Flatz, Rita Gerardy-Schahn, Anja Münster-Kühnel, Johannes Stadlmann, Laurence Zitvogel, Josef M. Penninger   +25 more
doaj   +2 more sources

Sialylation: A Cloak for Tumors to Trick the Immune System in the Microenvironment

Biology, 2023
The tumor microenvironment (TME), where the tumor cells incite the surrounding normal cells to create an immune suppressive environment, reduces the effectiveness of immune responses during cancer development.
Xiaoman Zhou, Kaijun Chi, Chairui Zhang, Quan Liu, Ganglong Yang   +4 more
doaj   +2 more sources

Lipoprotein sialylation in atherosclerosis: Lessons from mice

Frontiers in Endocrinology, 2022
Sialylation is a dynamically regulated modification, which commonly occurs at the terminal of glycan chains in glycoproteins and glycolipids in eukaryotic cells.
Liming Yu, Jun Peng, Chieko Mineo, Chieko Mineo   +3 more
doaj   +1 more source

Deficiency in ST6GAL1, one of the two α2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease

Frontiers in Molecular Biosciences, 2022
Prion diseases are a group of fatal neurodegenerative diseases caused by misfolding of the normal cellular form of the prion protein or PrPC, into a disease-associated self-replicating state or PrPSc.
Natallia Makarava, Natallia Makarava, Elizaveta Katorcha, Elizaveta Katorcha, Jennifer Chen-Yu Chang, Jennifer Chen-Yu Chang, Joseph T. Y. Lau, Ilia V. Baskakov, Ilia V. Baskakov   +8 more
doaj   +1 more source

Enzymatic sialylation of IgA1 O-glycans: implications for studies of IgA nephropathy. [PDF]

PLoS ONE, 2014
Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc).
Kazuo Takahashi, Milan Raska, Milada Stuchlova Horynova, Stacy D Hall, Knud Poulsen, Mogens Kilian, Yoshiyuki Hiki, Yukio Yuzawa, Zina Moldoveanu, Bruce A Julian, Matthew B Renfrow, Jan Novak   +11 more
doaj   +1 more source

Characterization of sialylation-related long noncoding RNAs to develop a novel signature for predicting prognosis, immune landscape, and chemotherapy response in colorectal cancer

Frontiers in Immunology, 2022
Aberrant sialylation plays a key biological role in tumorigenesis and metastasis, including tumor cell survival and invasion, immune evasion, angiogenesis, and resistance to therapy.
Mingxuan Zhou, Silin Lv, Yufang Hou, Rixin Zhang, Weiqi Wang, Zheng Yan, Tiegang Li, Wenqiang Gan, Zifan Zeng, Fang Zhang, Min Yang   +10 more
doaj   +1 more source