Results 31 to 40 of about 17,651 (213)
Frontiers in Chemistry, 2020 Sialylation, a post-translational modification that impacts the structure, activity, and longevity of glycoproteins has been thought to be controlled primarily by the expression of sialyltransferases (STs).
Christopher T. Saeui +17 more
doaj +1 more source
The enzymatic synthesis of sialyl-lactose [PDF]
Biochemical and Biophysical Research Communications, 1963 Abstract Sialyl-lactose (SL) was first isolated from lactating rat mammary gland by Trucco and Caputto (1954) . In subsequent extensive studies on milk oligosaccharides, Kuhn and coworkers ( Kuhn and Brossmer, 1958 , Kuhn, 1959 ) obtained two isomers of SL from human milk, one being identical to SL from bovine colostrum. Bovine SL was shown to be N-
Jourdian, George W. +2 more
openaire +3 more sources
Redox-Controlled Site-Specific α2–6-Sialylation
, 2019 The first bacterial α2–6-sialyltransferase cloned from Photobacterium damselae (Pd2,6ST) has been widely applied for the synthesis of various α2–6-linked sialosides.
Jiansong Cheng (268199) +10 more
core +1 more source
Successfully Engineering a Bacterial Sialyltransferase for Regioselective α2,6-sialylation
, 2018 A β-galactoside α2,6-sialyltransferase from Photobacterium damselae (Pd2,6ST) that is capable of sialylating both terminal and internal galactose and N-acetylgalactosamine was herein redesigned for regioselectively producing terminal α2,6-sialosides ...
Jiansong Cheng (268199) +17 more
core +1 more source
In Vitro Sialylation of Recombinant Alpha-1-Antitrypsin using α2,6 Sialyltransferase from Photobacterium Damselae Produces Di-sialyl Galactose Motifs in N-Glycans [PDF]
, 2019 Sialic acids are cell surface sugars present in many animal glycoproteins and are of particular interest in biopharmaceuticals, where lack of sialylation can reduce bioactivity.
Chris, Gray +12 more
core +2 more sources
Efficient Sialylation with Phenyltrifluoroacetimidates as Leaving Groups
, 2016 Sialylation with N-phenyltrifluoroacetimidates as leaving groups and a catalytic amount of TMSOTf as promoter compares favorably with the previous protocols for direct sialylation and expand in essence the scope of the Schmidt glycosylation ...
Sutang Cai (2224447), Biao Yu (1466188)
core +2 more sources
Automated synthesis of sialylated oligosaccharides [PDF]
Beilstein Journal of Organic Chemistry, 2012 Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules.
Esposito, Davide +4 more
openaire +6 more sources
PLoS Pathogens, 2014 The central event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrP(C)) into the disease-associated, transmissible form (PrP(Sc)).
Elizaveta Katorcha +4 more
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness +11 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu +23 more
wiley +1 more source