Results 21 to 30 of about 17,651 (213)

Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila

eLife, 2023
Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. Sialylation relies on a dedicated pathway involving evolutionarily conserved enzymes, including CMP-sialic acid ...
Hilary Scott, Boris Novikov, Berrak Ugur, Brooke Allen, Ilya Mertsalov, Pedro Monagas-Valentin, Melissa Koff, Sarah Baas Robinson, Kazuhiro Aoki, Raisa Veizaj, Dirk J Lefeber, Michael Tiemeyer, Hugo Bellen, Vladislav Panin   +13 more
doaj   +1 more source

Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers [PDF]

Biology, 2017
The tetrasaccharide structures Siaα2,3Galβ1,3(Fucα1,4)GlcNAc and Siaα2,3Galβ1,4(Fucα1,3)GlcNAc constitute the epitopes of the carbohydrate antigens sialyl-Lewis a (sLea) and sialyl-Lewis x (sLex), respectively, and are the minimal requirement for selectin binding to their counter-receptors.
Marco Trinchera, Adele Aronica, Fabio Dall’Olio   +2 more
openaire   +3 more sources

Sialylation regulates migration in chronic lymphocytic leukemia [PDF]

, 2023
Sialylation is the terminal addition of sialic acid to underlying glycans and plays a prominent role in cell adhesion and immune regulation. Sialylated structures found on adhesion molecules, such as CD49d, mediate the interactions between cancer cells ...
Marina Cerreto, Guarini, Anna, Ilaria Del Giudice, Soscia, Roberta, Maria Laura Milani, Milani, Maria Laura, Alessandro Natoni, Anna Guarini, Del Giudice, Ilaria, Cerreto, Marina, Stefania Intoppa, Intoppa, Stefania, Natoni, Alessandro, Foà, Robin, De Propris, Maria Stefania, Maria Stefania De Propris, Peragine, Nadia, Robin Foà, Nadia Peragine, Roberta Soscia   +19 more
core   +1 more source

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women

Arthritis Research & Therapy, 2018
Background Rheumatoid arthritis (RA) preferentially affects women, with the peak incidence coinciding with estrogen decrease in menopause. Estrogen (E2) may therefore have intrinsic immune-regulatory properties that vanish with menopause.
Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d’Elia, Georg Schett   +13 more
doaj   +1 more source

Idursulfase pharmacokinetics, cellular uptake, and pharmacodynamics: Effect of sialylation and manufacturing process

Engineering Reports, 2020
Recombinant iduronate‐2‐sulfatase (idursulfase) is available for the treatment of mucopolysaccharidosis II (MPS II). The effectiveness of this glycoprotein may depend on post‐translational modifications such as glycosylation and sialylation during ...
Antony R. Garcia, Justin Lamsa, David A. H. Whiteman, Joseph Muenzer   +3 more
doaj   +1 more source

Sialylation in the nervous system: Functions and mechanisms. [PDF]

J Biol Chem
Glycoprotein sialylation represents a critical posttranslational modification with diverse biological roles in animals. This review explores its multifaceted functions in the nervous system, with particular emphasis on neurophysiology, homeostasis, and ...
Koles K, Repnikova E, Novikov B, Panin V.   +3 more
europepmc   +3 more sources

Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause

Frontiers in Endocrinology, 2023
IntroductionThe glycosylation of immunoglobulin (Ig) G regulates IgG interaction capability with Fc gamma receptors found in all immune cells. In pathogenic conditions, estrogen can impact IgG levels and glycosylation.
Priti Gupta, Priti Gupta, Priti Gupta, Tibor Sághy, Tibor Sághy, Tibor Sághy, Jauquline Nordqvist, Jonas Nilsson, Hans Carlsten, Karin Horkeby, Petra Henning, Cecilia Engdahl, Cecilia Engdahl, Cecilia Engdahl   +13 more
doaj   +1 more source

Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver

Haematologica, 2020
Sialic acid is a common terminal residue of glycans on proteins and acidic sphingolipids such as gangliosides with important biological functions. The sialylation process is controlled by more than 20 different sialyltransferases, many of which exhibit ...
Xiaolin Ma, Yun Li, Yuji Kondo, Huiping Shi, Jingjing Han, Yizhi Jiang, Xia Bai, Stephanie A. Archer-Hartmann, Parastoo Azadi, Changgeng Ruan, Jianxin Fu, Lijun Xia   +11 more
doaj   +1 more source

IgG Glycosylation Patterns May Identify Distinct Clinical Trajectories in Fibromyalgia Patients: A Longitudinal Pilot Study. [PDF]

Eur J Pain
ABSTRACT Background Altered immunoglobulin G (IgG) glycosylation was implicated in various conditions, but its role in fibromyalgia (FM) remains unclear. This study investigated IgG glycosylation patterns in FM patients and associations between glycosylation changes and clinical profiles.
Kung LC, Nhu NT, Yu YY, Tsai IL, Kang JH.   +4 more
europepmc   +2 more sources

Inhibition of chemokine (C-C motif) receptor 7 sialylation suppresses CCL19-stimulated proliferation, invasion and anti-anoikis. [PDF]

PLoS ONE, 2014
Chemokine (C-C motif) receptor 7 (CCR7) is involved in lymph-node homing of naive and regulatory T cells and lymphatic metastasis of cancer cells. Sialic acids comprise a group of monosaccharide units that are added to the terminal position of the ...
Mei-Lin Su, Tsung-Ming Chang, Chi-Hsiang Chiang, Han-Chen Chang, Ming-Feng Hou, Wen-Shan Li, Wen-Chun Hung   +6 more
doaj   +1 more source