Multifaceted role of sialylation in prion diseases
Frontiers in Neuroscience, 2016 Mammalian prion or PrPSc is a proteinaceous infectious agent that consists of a misfolded, self-replicating state of a sialoglycoprotein called the prion protein or PrPC. Sialylation of the prion protein N-linked glycans was discovered more than 30 years
Ilia V Baskakov +3 more
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Sialylation of Campylobacter jejuni lipo-oligosaccharides: impact on phagocytosis and cytokine production in mice. [PDF]
PLoS ONE, 2012 Guillain-Barré syndrome (GBS) is a post-infectious polyradiculoneuropathy, frequently associated with antecedent Campylobacter jejuni (C. jejuni) infection. The presence of sialic acid on C.
Ruth Huizinga +10 more
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Bazedoxifene does not share estrogens effects on IgG sialylation.
PLoS ONE, 2023 The incidence of rheumatoid arthritis (RA) increases at the same time as menopause when estrogen level decreases. Estrogen treatment is known to reduce the IgG pathogenicity by increasing the sialylation grade on the terminal glycan chain of the Fc ...
Priti Gupta +4 more
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Stable Protein Sialylation in Physcomitrella [PDF]
Frontiers in Plant Science, 2020 Abstract Recombinantly produced proteins are indispensable tools for medical applications. Since the majority of them are glycoproteins, their N -glycosylation profiles are major determinants for their activity, structural properties and safety.
Lennard L. Bohlender +16 more
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Highly Variable Sialylation Status of Donor-Specific Antibodies Does Not Impact Humoral Rejection Outcomes [PDF]
Frontiers in Immunology, 2019 Clinical outcome in antibody-mediated rejection (AMR) shows high inter-individual heterogeneity. Sialylation status of the Fc fragment of IgGs is variable, which could modulate their ability to bind to C1q and/or Fc receptors. In this translational study,
Thomas Barba +27 more
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Scientific ReportsMucus stasis is a pathologic hallmark of muco-obstructive diseases, including cystic fibrosis (CF). Mucins, the principal component of mucus, are extensively modified with hydroxyl (O)-linked glycans, which are largely terminated by sialic acid.
Elex S. Harris +8 more
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Cellular and Molecular Engineering of Glycan Sialylation in Heterologous Systems
Molecules, 2021 Glycans have been shown to play a key role in many biological processes, such as signal transduction, immunogenicity, and disease progression. Among the various glycosylation modifications found on cell surfaces and in biomolecules, sialylation is ...
Ryoma Hombu +2 more
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Regulation of alpha 2,6-sialylation in B-cells and the role of sialylation in the pathogenesis of Rheumatoid Arthritis [PDF]
, 2020 Sialylation is a common post-translational modification involving the addition of sialic acid to glycoprotein chains. Sialic acid within the Fc fragment of IgG molecules can influence binding to Fc receptors.
Johnston, Lynsey Elinor
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Dehydrative Sialylation with C2-Hemiketal Sialyl Donors [PDF]
Organic Letters, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Jannine M, Haberman, David Y, Gin
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Sialylation Fine-Tunes Glycoprotein Structural Microheterogeneity Associated with Alzheimer’s Disease as Captured by Native Ion Mobility-Mass Spectrometry [PDF]
, 2020 Protein sialylation has been closely linked to many diseases including Alzheimer’s disease (AD) and is broadly implicated in therapeutics in a terminal structure-sensitive manner. However, how sialylation structurally affects mature glycoproteins and how
Ashita, Nair +9 more
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